Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
1_MEALG 6_ FLKLE 11_ VNGPM 16_ VTVAL 21_ SVALL 26_ ALLKW 31_ YSTSA 36_ FSRLE 41_ KLGLR 46_ HPKPS 51_ PFIGN 56_ LTFFR 61_ QGFWE 66_ SQMEL 71_ RKLYG 76_ PLCGY 81_ YLGRR 86_ MFIVI 91_ SEPDM 96_ IKQVL 101_ VENFS 106_ NFTNR 111_ MASGL 116_ EFKSV 121_ ADSVL 126_ FLRDK 131_ RWEEV 136_ RGALM 141_ SAFSP 146_ EKLNE 151_ MVPLI 156_ SQACD 161_ LLLAH 166_ LKRYA 171_ ESGDA 176_ FDIQR 181_ CYCNY 186_ TTDVV 191_ ASVAF 196_ GTPVD 201_ SWQAP 206_ EDPFV 211_ KHCKR 216_ FFEFC 221_ IPRPI 226_ LVLLL 231_ SFPSI 236_ MVPLA 241_ RILPN 246_ KNRDE 251_ LNGFF 256_ NKLIR 261_ NVIAL 266_ RDQQA 271_ AEERR 276_ RDFLQ 281_ MVLDA 286_ RHSAS 291_ PMGVQ 296_ DFDIV 301_ RDVFS 306_ STGCK 311_ PNPSR 316_ QHQPS 321_ PMARP 326_ LTVDE 331_ IVGQA 336_ FIFLI 341_ AGYEI 346_ ITNTL 351_ SFATY 356_ LLATN 361_ PDCQE 366_ KLLRE 371_ VDVFK 376_ EKHMA 381_ PEFCS 386_ LEEGL 391_ PYLDM 396_ VIAET 401_ LRMYP 406_ PAFRF 411_ TREAA 416_ QDCEV 421_ LGQRI 426_ PAGAV 431_ LEMAV 436_ GALHH 441_ DPEHW 446_ PSPET 451_ FNPER 456_ FTAEA 461_ RQQHR 466_ PFTYL 471_ PFGAG 476_ PRSCL 481_ GVRLG 486_ LLEVK 491_ LTLLH 496_ VLHKF 501_ RFQAC 506_ PETQV 511_ PLQLE 516_ SKSAL 521_ GPKNG 526_VYIKI
1: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, PubMed:24009185, PubMed:8436233, PubMed:9873013). Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:22735388, PubMed:9873013). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323)