A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein)
1_METTI 6_ SEIHV 11_ ENKDE 16_ KRSAE 21_ GSPGA 26_ ERQKE 31_ KASML 36_ CFKRR 41_ KKAAK 46_ ALKPK 51_ AGSEA 56_ ADVAR 61_ KCPQE 66_ AGASD 71_ QPEPT 76_ RGAWA 81_ SLKRL 86_ VTRRK 91_ RSESS 96_ KQQKP 101_ LEGEM 106_ QPAIN 111_ AEDAD 116_ LSKKK 121_ AKSRL 126_ KIPCI 131_ KFPRG 136_ PKRSN 141_ HSKII 146_ EDSDC 151_ SIKVQ 156_ EEAEI 161_ LDIQT 166_ QTPLN 171_ DQATK 176_ AKSTQ 181_ DLSEG 186_ ISRKD 191_ GDEVC 196_ ESNVS 201_ NSTTS 206_ GEKVI 211_ SVELG 216_ LDNGH 221_ SAIQT 226_ GTLIL 231_ EEIET 236_ IKEKQ 241_ DVQPQ 246_ QASPL 251_ ETSET 256_ DHQQP 261_ VLSDV 266_ PPLPA 271_ IPDQQ 276_ IVEEA 281_ SNSTL 286_ ESAPN 291_ GKDYE 296_ STEIV 301_ AEETK 306_ PKDTE 311_ LSQES 316_ DFKEN 321_ GITEE 326_ KSKSE 331_ ESKRM 336_ EPIAI 341_ IITDT 346_ EISEF 351_ DVTKS 356_ KNVPK 361_ QFLIS 366_ AENEQ 371_ VGVFA 376_ NDNGF 381_ EDRTS 386_ EQYET 391_ LLIET 396_ ASSLV 401_ KNAIQ 406_ LSIEQ 411_ LVNEM 416_ ASDDN 421_KINNL
1: Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses (PubMed:33941685)