Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6)
1_MTPHR 6_ LLPPL 11_ LLLLA 16_ LLLAA 21_ SPGGA 26_ LARCP 31_ GCGQG 36_ VQAGC 41_ PGGCV 46_ EEEDG 51_ GSPAE 56_ GCAEA 61_ EGCLR 66_ REGQE 71_ CGVYT 76_ PNCAP 81_ GLQCH 86_ PPKDD 91_ EAPLR 96_ ALLLG 101_ RGRCL 106_ PARAP 111_ AVAEE 116_ NPKES 121_ KPQAG 126_ TARPQ 131_ DVNRR 136_ DQQRN 141_ PGTST 146_ TPSQP 151_ NSAGV 156_ QDTEM 161_ GPCRR 166_ HLDSV 171_ LQQLQ 176_ TEVYR 181_ GAQTL 186_ YVPNC 191_ DHRGF 196_ YRKRQ 201_ CRSSQ 206_ GQRRG 211_ PCWCV 216_ DRMGK 221_ SLPGS 226_ PDGNG 231_SSSCP
1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225)