Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5)
1_MVLLT 6_ AVLLL 11_ LAAYA 16_ GPAQS 21_ LGSFV 26_ HCEPC 31_ DEKAL 36_ SMCPP 41_ SPLGC 46_ ELVKE 51_ PGCGC 56_ CMTCA 61_ LAEGQ 66_ SCGVY 71_ TERCA 76_ QGLRC 81_ LPRQD 86_ EEKPL 91_ HALLH 96_ GRGVC 101_ LNEKS 106_ YREQV 111_ KIERD 116_ SREHE 121_ EPTTS 126_ EMAEE 131_ TYSPK 136_ IFRPK 141_ HTRIS 146_ ELKAE 151_ AVKKD 156_ RRKKL 161_ TQSKF 166_ VGGAE 171_ NTAHP 176_ RIISA 181_ PEMRQ 186_ ESEQG 191_ PCRRH 196_ MEASL 201_ QELKA 206_ SPRMV 211_ PRAVY 216_ LPNCD 221_ RKGFY 226_ KRKQC 231_ KPSRG 236_ RKRGI 241_ CWCVD 246_ KYGMK 251_ LPGME 256_ YVDGD 261_ FQCHT 266_FDSSN
1: Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs (PubMed:20345844, PubMed:26103640). Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (PubMed:36949068)