Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta)
1_MSSGT 6_ MKFNG 11_ YLRVR 16_ IGEAV 21_ GLQPT 26_ RWSLR 31_ HSLFK 36_ KGHQL 41_ LDPYL 46_ TVSVD 51_ QVRVG 56_ QTSTK 61_ QKTNK 66_ PTYNE 71_ EFCAN 76_ VTDGG 81_ HLELA 86_ VFHET 91_ PLGYD 96_ HFVAN 101_ CTLQF 106_ QELLR 111_ TTGAS 116_ DTFEG 121_ WVDLE 126_ PEGKV 131_ FVVIT 136_ LTGSF 141_ TEATL 146_ QRDRI 151_ FKHFT 156_ RKRQR 161_ AMRRR 166_ VHQIN 171_ GHKFM 176_ ATYLR 181_ QPTYC 186_ SHCRE 191_ FIWGV 196_ FGKQG 201_ YQCQV 206_ CTCVV 211_ HKRCH 216_ HLIVT 221_ ACTCQ 226_ NNINK 231_ VDSKI 236_ AEQRF 241_ GINIP 246_ HKFSI 251_ HNYKV 256_ PTFCD 261_ HCGSL 266_ LWGIM 271_ RQGLQ 276_ CKICK 281_ MNVHI 286_ RCQAN 291_ VAPNC 296_ GVNAV 301_ ELAKT 306_ LAGMG 311_ LQPGN 316_ ISPTS 321_ KLVSR 326_ STLRR 331_ QGKES 336_ SKEGN 341_ GIGVN 346_ SSNRL 351_ GIDNF 356_ EFIRV 361_ LGKGS 366_ FGKVM 371_ LARVK 376_ ETGDL 381_ YAVKV 386_ LKKDV 391_ ILQDD 396_ DVECT 401_ MTEKR 406_ ILSLA 411_ RNHPF 416_ LTQLF 421_ CCFQT 426_ PDRLF 431_ FVMEF 436_ VNGGD 441_ LMFHI 446_ QKSRR 451_ FDEAR 456_ ARFYA 461_ AEIIS 466_ ALMFL 471_ HDKGI 476_ IYRDL 481_ KLDNV 486_ LLDHE 491_ GHCKL 496_ ADFGM 501_ CKEGI 506_ CNGVT 511_ TATFC 516_ GTPDY 521_ IAPEI 526_ LQEML 531_ YGPAV 536_ DWWAM 541_ GVLLY 546_ EMLCG 551_ HAPFE 556_ AENED 561_ DLFEA 566_ ILNDE 571_ VVYPT 576_ WLHED 581_ ATGIL 586_ KSFMT 591_ KNPTM 596_ RLGSL 601_ TQGGE 606_ HAILR 611_ HPFFK 616_ EIDWA 621_ QLNHR 626_ QIEPP 631_ FRPRI 636_ KSRED 641_ VSNFD 646_ PDFIK 651_ EEPVL 656_ TPIDE 661_ GHLPM 666_ INQDE 671_ FRNFS 676_YVSPE
1: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization