Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)
1_MAVLA 6_ ALLRS 11_ GARSR 16_ SPLLR 21_ RLVQE 26_ IRYVE 31_ RSYVS 36_ KPTLK 41_ EVVIV 46_ SATRT 51_ PIGSF 56_ LGSLS 61_ LLPAT 66_ KLGSI 71_ AIQGA 76_ IEKAG 81_ IPKEE 86_ VKEAY 91_ MGNVL 96_ QGGEG 101_ QAPTR 106_ QAVLG 111_ AGLPI 116_ STPCT 121_ TINKV 126_ CASGM 131_ KAIMM 136_ ASQSL 141_ MCGHQ 146_ DVMVA 151_ GGMES 156_ MSNVP 161_ YVMNR 166_ GSTPY 171_ GGVKL 176_ EDLIV 181_ KDGLT 186_ DVYNK 191_ IHMGS 196_ CAENT 201_ AKKLN 206_ IARNE 211_ QDAYA 216_ INSYT 221_ RSKAA 226_ WEAGK 231_ FGNEV 236_ IPVTV 241_ TVKGQ 246_ PDVVV 251_ KEDEE 256_ YKRVD 261_ FSKVP 266_ KLKTV 271_ FQKEN 276_ GTVTA 281_ ANAST 286_ LNDGA 291_ AALVL 296_ MTADA 301_ AKRLN 306_ VTPLA 311_ RIVAF 316_ ADAAV 321_ EPIDF 326_ PIAPV 331_ YAASM 336_ VLKDV 341_ GLKKE 346_ DIAMW 351_ EVNEA 356_ FSLVV 361_ LANIK 366_ MLEID 371_ PQKVN 376_ INGGA 381_ VSLGH 386_ PIGMS 391_ GARIV 396_ GHLTH 401_ ALKQG 406_ EYGLA 411_ SICNG 416_ GGGAS 421_AMLIQ
1: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475)