Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa)
1_MRGMK 6_ LLGAL 11_ LALAA 16_ LLQGA 21_ VSLKI 26_ AAFNI 31_ QTFGE 36_ TKMSN 41_ ATLVS 46_ YIVQI 51_ LSRYD 56_ IALVQ 61_ EVRDS 66_ HLTAV 71_ GKLLD 76_ NLNQD 81_ APDTY 86_ HYVVS 91_ EPLGR 96_ NSYKE 101_ RYLFV 106_ YRPDQ 111_ VSAVD 116_ SYYYD 121_ DGCEP 126_ CGNDT 131_ FNREP 136_ AIVRF 141_ FSRFT 146_ EVREF 151_ AIVPL 156_ HAAPG 161_ DAVAE 166_ IDALY 171_ DVYLD 176_ VQEKW 181_ GLEDV 186_ MLMGD 191_ FNAGC 196_ SYVRP 201_ SQWSS 206_ IRLWT 211_ SPTFQ 216_ WLIPD 221_ SADTT 226_ ATPTH 231_ CAYDR 236_ IVVAG 241_ MLLRG 246_ AVVPD 251_ SALPF 256_ NFQAA 261_ YGLSD 266_ QLAQA 271_ ISDHY 276_PVEVM
1: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:11241278, PubMed:2251263, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity)