Cyclin-C (SRB11 homolog) (hSRB11)
1_MAGNF 6_ WQSSH 11_ YLQWI 16_ LDKQD 21_ LLKER 26_ QKDLK 31_ FLSEE 36_ EYWKL 41_ QIFFT 46_ NVIQA 51_ LGEHL 56_ KLRQQ 61_ VIATA 66_ TVYFK 71_ RFYAR 76_ YSLKS 81_ IDPVL 86_ MAPTC 91_ VFLAS 96_ KVEEF 101_ GVVSN 106_ TRLIA 111_ AATSV 116_ LKTRF 121_ SYAFP 126_ KEFPY 131_ RMNHI 136_ LECEF 141_ YLLEL 146_ MDCCL 151_ IVYHP 156_ YRPLL 161_ QYVQD 166_ MGQED 171_ MLLPL 176_ AWRIV 181_ NDTYR 186_ TDLCL 191_ LYPPF 196_ MIALA 201_ CLHVA 206_ CVVQQ 211_ KDARQ 216_ WFAEL 221_ SVDME 226_ KILEI 231_ IRVIL 236_ KLYEQ 241_ WKNFD 246_ ERKEM 251_ ATILS 256_ KMPKP 261_ KPPPN 266_ SEGEQ 271_ GPNGS 276_QNSSY
1: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex