Cytochrome P450 2F1 (EC 1.14.14.1) (CYPIIF1)
1_MDSIS 6_ TAILL 11_ LLLAL 16_ VCLLL 21_ TLSSR 26_ DKGKL 31_ PPGPR 36_ PLSIL 41_ GNLLL 46_ LCSQD 51_ MLTSL 56_ TKLSK 61_ EYGSM 66_ YTVHL 71_ GPRRV 76_ VVLSG 81_ YQAVK 86_ EALVD 91_ QGEEF 96_ SGRGD 101_ YPAFF 106_ NFTKG 111_ NGIAF 116_ SSGDR 121_ WKVLR 126_ QFSIQ 131_ ILRNF 136_ GMGKR 141_ SIEER 146_ ILEEG 151_ SFLLA 156_ ELRKT 161_ EGEPF 166_ DPTFV 171_ LSRSV 176_ SNIIC 181_ SVLFG 186_ SRFDY 191_ DDERL 196_ LTIIR 201_ LINDN 206_ FQIMS 211_ SPWGE 216_ LYDIF 221_ PSLLD 226_ WVPGP 231_ HQRIF 236_ QNFKC 241_ LRDLI 246_ AHSVH 251_ DHQAS 256_ LDPRS 261_ PRDFI 266_ QCFLT 271_ KMAEE 276_ KEDPL 281_ SHFHM 286_ DTLLM 291_ TTHNL 296_ LFGGT 301_ KTVST 306_ TLHHA 311_ FLALM 316_ KYPKV 321_ QARVQ 326_ EEIDL 331_ VVGRA 336_ RLPAL 341_ KDRAA 346_ MPYTD 351_ AVIHE 356_ VQRFA 361_ DIIPM 366_ NLPHR 371_ VTRDT 376_ AFRGF 381_ LIPKG 386_ TDVIT 391_ LLNTV 396_ HYDPS 401_ QFLTP 406_ QEFNP 411_ EHFLD 416_ ANQSF 421_ KKSPA 426_ FMPFS 431_ AGRRL 436_ CLGES 441_ LARME 446_ LFLYL 451_ TAILQ 456_ SFSLQ 461_ PLGAP 466_ EDIDL 471_ TPLSS 476_ GLGNL 481_ PRPFQ 486_LCLRP
1: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine