Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)
1_MAPNG 6_ TASSF 11_ CLDST 16_ ACKIT 21_ ITVVL 26_ AVLIL 31_ ITVAG 36_ NVVVC 41_ LAVGL 46_ NRRLR 51_ NLTNC 56_ FIVSL 61_ AITDL 66_ LLGLL 71_ VLPFS 76_ AIYQL 81_ SCKWS 86_ FGKVF 91_ CNIYT 96_ SLDVM 101_ LCTAS 106_ ILNLF 111_ MISLD 116_ RYCAV 121_ MDPLR 126_ YPVLV 131_ TPVRV 136_ AISLV 141_ LIWVI 146_ SITLS 151_ FLSIH 156_ LGWNS 161_ RNETS 166_ KGNHT 171_ TSKCK 176_ VQVNE 181_ VYGLV 186_ DGLVT 191_ FYLPL 196_ LIMCI 201_ TYYRI 206_ FKVAR 211_ DQAKR 216_ INHIS 221_ SWKAA 226_ TIREH 231_ KATVT 236_ LAAVM 241_ GAFII 246_ CWFPY 251_ FTAFV 256_ YRGLR 261_ GDDAI 266_ NEVLE 271_ AIVLW 276_ LGYAN 281_ SALNP 286_ ILYAA 291_ LNRDF 296_ RTGYQ 301_ QLFCC 306_ RLANR 311_ NSHKT 316_ SLRSN 321_ ASQLS 326_ RTQSR 331_ EPRQQ 336_ EEKPL 341_ KLQVW 346_ SGTEV 351_TAPQG
1: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity)