Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
1_MAAAS 6_ YDQLL 11_ KQVEA 16_ LKMEN 21_ SNLRQ 26_ ELEDN 31_ SNHLT 36_ KLETE 41_ ASNMK 46_ EVLKQ 51_ LQGSI 56_ EDEAM 61_ ASSGQ 66_ IDLLE 71_ RLKEL 76_ NLDSS 81_ NFPGV 86_ KLRSK 91_ MSLRS 96_ YGSRE 101_ GSVSS 106_ RSGEC 111_ SPVPM 116_ GSFPR 121_ RGFVN 126_ GSRES 131_ TGYLE 136_ ELEKE 141_ RSLLL 146_ ADLDK 151_ EEKEK 156_ DWYYA 161_ QLQNL 166_ TKRID 171_ SLPLT 176_ ENFSL 181_ QTDMT 186_ RRQLE 191_ YEARQ 196_ IRVAM 201_ EEQLG 206_ TCQDM 211_ EKRAQ 216_ RRIAR 221_ IQQIE 226_ KDILR 231_ IRQLL 236_ QSQAT 241_ EAERS 246_ SQNKH 251_ ETGSH 256_ DAERQ 261_ NEGQG 266_ VGEIN 271_ MATSG 276_ NGQGS 281_ TTRMD 286_ HETAS 291_ VLSSS 296_ STHSA 301_ PRRLT 306_ SHLGT 311_ KVEMV 316_ YSLLS 321_ MLGTH 326_ DKDDM 331_ SRTLL 336_ AMSSS 341_ QDSCI 346_ SMRQS 351_ GCLPL 356_ LIQLL 361_ HGNDK 366_ DSVLL 371_ GNSRG 376_ SKEAR 381_ ARASA 386_ ALHNI 391_ IHSQP 396_ DDKRG 401_ RREIR 406_ VLHLL 411_ EQIRA 416_ YCETC 421_ WEWQE 426_ AHEPG 431_ MDQDK 436_ NPMPA 441_ PVEHQ 446_ ICPAV 451_ CVLMK 456_ LSFDE 461_ EHRHA 466_ MNELG 471_ GLQAI 476_ AELLQ 481_ VDCEM 486_ YGLTN 491_ DHYSI 496_ TLRRY 501_ AGMAL 506_ TNLTF 511_ GDVAN 516_ KATLC 521_ SMKGC 526_ MRALV 531_ AQLKS 536_ ESEDL 541_ QQVIA 546_ SVLRN 551_ LSWRA 556_ DVNSK 561_ KTLRE 566_ VGSVK 571_ ALMEC 576_ ALEVK 581_ KESTL 586_ KSVLS 591_ ALWNL 596_ SAHCT 601_ ENKAD 606_ ICAVD 611_ GALAF 616_ LVGTL 621_ TYRSQ 626_ TNTLA 631_ IIESG 636_ GGILR 641_ NVSSL 646_ IATNE 651_ DHRQI 656_ LRENN 661_ CLQTL 666_ LQHLK 671_ SHSLT 676_ IVSNA 681_ CGTLW 686_ NLSAR 691_ NPKDQ 696_ EALWD 701_ MGAVS 706_ MLKNL 711_ IHSKH 716_ KMIAM 721_ GSAAA 726_ LRNLM 731_ ANRPA 736_ KYKDA 741_ NIMSP 746_ GSSLP 751_ SLHVR 756_ KQKAL 761_ EAELD 766_ AQHLS 771_ ETFDN 776_ IDNLS 781_ PKASH 786_ RSKQR 791_ HKQSL 796_ YGDYV 801_ FDTNR 806_ HDDNR 811_ SDNFN 816_ TGNMT 821_ VLSPY 826_ LNTTV 831_ LPSSS 836_ SSRGS 841_ LDSSR 846_ SEKDR 851_ SLERE 856_ RGIGL 861_ GNYHP 866_ ATENP 871_ GTSSK 876_ RGLQI 881_ STTAA 886_ QIAKV 891_ MEEVS 896_ AIHTS 901_ QEDRS 906_ SGSTT 911_ ELHCV 916_ TDERN 921_ ALRRS 926_ SAAHT 931_ HSNTY 936_ NFTKS 941_ ENSNR 946_ TCSMP 951_ YAKLE 956_ YKRSS 961_ NDSLN 966_ SVSSS 971_ DGYGK 976_ RGQMK 981_ PSIES 986_ YSEDD 991_ ESKFC 996_ SYGQY 1001_ PADLA 1006_ HKIHS 1011_ ANHMD 1016_ DNDGE 1021_ LDTPI 1026_ NYSLK 1031_ YSDEQ 1036_ LNSGR 1041_ QSPSQ 1046_ NERWA 1051_ RPKHI 1056_ IEDEI 1061_ KQSEQ 1066_ RQSRN 1071_ QSTTY 1076_ PVYTE 1081_ STDDK 1086_ HLKFQ 1091_ PHFGQ 1096_ QECVS 1101_ PYRSR 1106_ GANGS 1111_ ETNRV 1116_ GSNHG 1121_ INQNV 1126_ SQSLC 1131_ QEDDY 1136_ EDDKP 1141_ TNYSE 1146_ RYSEE 1151_ EQHEE 1156_ EERPT 1161_ NYSIK 1166_ YNEEK 1171_ RHVDQ 1176_ PIDYS 1181_ LKYAT 1186_ DIPSS 1191_ QKQSF 1196_ SFSKS 1201_ SSGQS 1206_ SKTEH 1211_ MSSSS 1216_ ENTST 1221_ PSSNA 1226_ KRQNQ 1231_ LHPSS 1236_ AQSRS 1241_ GQPQK 1246_ AATCK 1251_ VSSIN 1256_ QETIQ 1261_ TYCVE 1266_ DTPIC 1271_ FSRCS 1276_ SLSSL 1281_ SSAED 1286_ EIGCN 1291_ QTTQE 1296_ ADSAN 1301_ TLQIA 1306_ EIKEK 1311_ IGTRS 1316_ AEDPV 1321_ SEVPA 1326_ VSQHP 1331_ RTKSS 1336_ RLQGS 1341_ SLSSE 1346_ SARHK 1351_ AVEFS 1356_ SGAKS 1361_ PSKSG 1366_ AQTPK 1371_ SPPEH 1376_ YVQET 1381_ PLMFS 1386_ RCTSV 1391_ SSLDS 1396_ FESRS 1401_ IASSV 1406_ QSEPC 1411_ SGMVS 1416_ GIISP 1421_ SDLPD 1426_ SPGQT 1431_ MPPSR 1436_ SKTPP 1441_ PPPQT 1446_ AQTKR 1451_ EVPKN 1456_ KAPTA 1461_ EKRES 1466_ GPKQA 1471_ AVNAA 1476_ VQRVQ 1481_ VLPDA 1486_ DTLLH 1491_ FATES 1496_ TPDGF 1501_ SCSSS 1506_ LSALS 1511_ LDEPF 1516_ IQKDV 1521_ ELRIM 1526_ PPVQE 1531_ NDNGN 1536_ ETESE 1541_ QPKES 1546_ NENQE 1551_ KEAEK 1556_ TIDSE 1561_ KDLLD 1566_ DSDDD 1571_ DIEIL 1576_ EECII 1581_ SAMPT 1586_ KSSRK 1591_ AKKPA 1596_ QTASK 1601_ LPPPV 1606_ ARKPS 1611_ QLPVY 1616_ KLLPS 1621_ QNRLQ 1626_ PQKHV 1631_ SFTPG 1636_ DDMPR 1641_ VYCVE 1646_ GTPIN 1651_ FSTAT 1656_ SLSDL 1661_ TIESP 1666_ PNELA 1671_ AGEGV 1676_ RGGAQ 1681_ SGEFE 1686_ KRDTI 1691_ PTEGR 1696_ STDEA 1701_ QGGKT 1706_ SSVTI 1711_ PELDD 1716_ NKAEE 1721_ GDILA 1726_ ECINS 1731_ AMPKG 1736_ KSHKP 1741_ FRVKK 1746_ IMDQV 1751_ QQASA 1756_ SSSAP 1761_ NKNQL 1766_ DGKKK 1771_ KPTSP 1776_ VKPIP 1781_ QNTEY 1786_ RTRVR 1791_ KNADS 1796_ KNNLN 1801_ AERVF 1806_ SDNKD 1811_ SKKQN 1816_ LKNNS 1821_ KVFND 1826_ KLPNN 1831_ EDRVR 1836_ GSFAF 1841_ DSPHH 1846_ YTPIE 1851_ GTPYC 1856_ FSRND 1861_ SLSSL 1866_ DFDDD 1871_ DVDLS 1876_ REKAE 1881_ LRKAK 1886_ ENKES 1891_ EAKVT 1896_ SHTEL 1901_ TSNQQ 1906_ SANKT 1911_ QAIAK 1916_ QPINR 1921_ GQPKP 1926_ ILQKQ 1931_ STFPQ 1936_ SSKDI 1941_ PDRGA 1946_ ATDEK 1951_ LQNFA 1956_ IENTP 1961_ VCFSH 1966_ NSSLS 1971_ SLSDI 1976_ DQENN 1981_ NKENE 1986_ PIKET 1991_ EPPDS 1996_ QGEPS 2001_ KPQAS 2006_ GYAPK 2011_ SFHVE 2016_ DTPVC 2021_ FSRNS 2026_ SLSSL 2031_ SIDSE 2036_ DDLLQ 2041_ ECISS 2046_ AMPKK 2051_ KKPSR 2056_ LKGDN 2061_ EKHSP 2066_ RNMGG 2071_ ILGED 2076_ LTLDL 2081_ KDIQR 2086_ PDSEH 2091_ GLSPD 2096_ SENFD 2101_ WKAIQ 2106_ EGANS 2111_ IVSSL 2116_ HQAAA 2121_ AACLS 2126_ RQASS 2131_ DSDSI 2136_ LSLKS 2141_ GISLG 2146_ SPFHL 2151_ TPDQE 2156_ EKPFT 2161_ SNKGP 2166_ RILKP 2171_ GEKST 2176_ LETKK 2181_ IESES 2186_ KGIKG 2191_ GKKVY 2196_ KSLIT 2201_ GKVRS 2206_ NSEIS 2211_ GQMKQ 2216_ PLQAN 2221_ MPSIS 2226_ RGRTM 2231_ IHIPG 2236_ VRNSS 2241_ SSTSP 2246_ VSKKG 2251_ PPLKT 2256_ PASKS 2261_ PSEGQ 2266_ TATTS 2271_ PRGAK 2276_ PSVKS 2281_ ELSPV 2286_ ARQTS 2291_ QIGGS 2296_ SKAPS 2301_ RSGSR 2306_ DSTPS 2311_ RPAQQ 2316_ PLSRP 2321_ IQSPG 2326_ RNSIS 2331_ PGRNG 2336_ ISPPN 2341_ KLSQL 2346_ PRTSS 2351_ PSTAS 2356_ TKSSG 2361_ SGKMS 2366_ YTSPG 2371_ RQMSQ 2376_ QNLTK 2381_ QTGLS 2386_ KNASS 2391_ IPRSE 2396_ SASKG 2401_ LNQMN 2406_ NGNGA 2411_ NKKVE 2416_ LSRMS 2421_ STKSS 2426_ GSESD 2431_ RSERP 2436_ VLVRQ 2441_ STFIK 2446_ EAPSP 2451_ TLRRK 2456_ LEESA 2461_ SFESL 2466_ SPSSR 2471_ PASPT 2476_ RSQAQ 2481_ TPVLS 2486_ PSLPD 2491_ MSLST 2496_ HSSVQ 2501_ AGGWR 2506_ KLPPN 2511_ LSPTI 2516_ EYNDG 2521_ RPAKR 2526_ HDIAR 2531_ SHSES 2536_ PSRLP 2541_ INRSG 2546_ TWKRE 2551_ HSKHS 2556_ SSLPR 2561_ VSTWR 2566_ RTGSS 2571_ SSILS 2576_ ASSES 2581_ SEKAK 2586_ SEDEK 2591_ HVNSI 2596_ SGTKQ 2601_ SKENQ 2606_ VSAKG 2611_ TWRKI 2616_ KENEF 2621_ SPTNS 2626_ TSQTV 2631_ SSGAT 2636_ NGAES 2641_ KTLIY 2646_ QMAPA 2651_ VSKTE 2656_ DVWVR 2661_ IEDCP 2666_ INNPR 2671_ SGRSP 2676_ TGNTP 2681_ PVIDS 2686_ VSEKA 2691_ NPNIK 2696_ DSKDN 2701_ QAKQN 2706_ VGNGS 2711_ VPMRT 2716_ VGLEN 2721_ RLNSF 2726_ IQVDA 2731_ PDQKG 2736_ TEIKP 2741_ GQNNP 2746_ VPVSE 2751_ TNESS 2756_ IVERT 2761_ PFSSS 2766_ SSSKH 2771_ SSPSG 2776_ TVAAR 2781_ VTPFN 2786_ YNPSP 2791_ RKSSA 2796_ DSTSA 2801_ RPSQI 2806_ PTPVN 2811_ NNTKK 2816_ RDSKT 2821_ DSTES 2826_ SGTQS 2831_ PKRHS 2836_GSYLV
1: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization