N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP)
1_METNF 6_ STPLN 11_ EYEEV 16_ SYESA 21_ GYTVL 26_ RILPL 31_ VVLGV 36_ TFVLG 41_ VLGNG 46_ LVIWV 51_ AGFRM 56_ TRTVT 61_ TICYL 66_ NLALA 71_ DFSFT 76_ ATLPF 81_ LIVSM 86_ AMGEK 91_ WPFGW 96_ FLCKL 101_ IHIVV 106_ DINLF 111_ GSVFL 116_ IGFIA 121_ LDRCI 126_ CVLHP 131_ VWAQN 136_ HRTVS 141_ LAMKV 146_ IVGPW 151_ ILALV 156_ LTLPV 161_ FLFLT 166_ TVTIP 171_ NGDTY 176_ CTFNF 181_ ASWGG 186_ TPEER 191_ LKVAI 196_ TMLTA 201_ RGIIR 206_ FVIGF 211_ SLPMS 216_ IVAIC 221_ YGLIA 226_ AKIHK 231_ KGMIK 236_ SSRPL 241_ RVLTA 246_ VVASF 251_ FICWF 256_ PFQLV 261_ ALLGT 266_ VWLKE 271_ MLFYG 276_ KYKII 281_ DILVN 286_ PTSSL 291_ AFFNS 296_ CLNPM 301_ LYVFV 306_ GQDFR 311_ ERLIH 316_ SLPTS 321_ LERAL 326_ SEDSA 331_ PTNDT 336_ AANSA 341_ SPPAE 346_TELQA
1: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts as a receptor for humanin (PubMed:15465011)