Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (hSTAR) (Intestinal guanylate cyclase)
1_MKTLL 6_ LDLAL 11_ WSLLF 16_ QPGWL 21_ SFSSQ 26_ VSQNC 31_ HNGSY 36_ EISVL 41_ MMGNS 46_ AFAEP 51_ LKNLE 56_ DAVNE 61_ GLEIV 66_ RGRLQ 71_ NAGLN 76_ VTVNA 81_ TFMYS 86_ DGLIH 91_ NSGDC 96_ RSSTC 101_ EGLDL 106_ LRKIS 111_ NAQRM 116_ GCVLI 121_ GPSCT 126_ YSTFQ 131_ MYLDT 136_ ELSYP 141_ MISAG 146_ SFGLS 151_ CDYKE 156_ TLTRL 161_ MSPAR 166_ KLMYF 171_ LVNFW 176_ KTNDL 181_ PFKTY 186_ SWSTS 191_ YVYKN 196_ GTETE 201_ DCFWY 206_ LNALE 211_ ASVSY 216_ FSHEL 221_ GFKVV 226_ LRQDK 231_ EFQDI 236_ LMDHN 241_ RKSNV 246_ IIMCG 251_ GPEFL 256_ YKLKG 261_ DRAVA 266_ EDIVI 271_ ILVDL 276_ FNDQY 281_ FEDNV 286_ TAPDY 291_ MKNVL 296_ VLTLS 301_ PGNSL 306_ LNSSF 311_ SRNLS 316_ PTKRD 321_ FALAY 326_ LNGIL 331_ LFGHM 336_ LKIFL 341_ ENGEN 346_ ITTPK 351_ FAHAF 356_ RNLTF 361_ EGYDG 366_ PVTLD 371_ DWGDV 376_ DSTMV 381_ LLYTS 386_ VDTKK 391_ YKVLL 396_ TYDTH 401_ VNKTY 406_ PVDMS 411_ PTFTW 416_ KNSKL 421_ PNDIT 426_ GRGPQ 431_ ILMIA 436_ VFTLT 441_ GAVVL 446_ LLLVA 451_ LLMLR 456_ KYRKD 461_ YELRQ 466_ KKWSH 471_ IPPEN 476_ IFPLE 481_ TNETN 486_ HVSLK 491_ IDDDK 496_ RRDTI 501_ QRLRQ 506_ CKYDK 511_ KRVIL 516_ KDLKH 521_ NDGNF 526_ TEKQK 531_ IELNK 536_ LLQID 541_ YYNLT 546_ KFYGT 551_ VKLDT 556_ MIFGV 561_ IEYCE 566_ RGSLR 571_ EVLND 576_ TISYP 581_ DGTFM 586_ DWEFK 591_ ISVLY 596_ DIAKG 601_ MSYLH 606_ SSKTE 611_ VHGRL 616_ KSTNC 621_ VVDSR 626_ MVVKI 631_ TDFGC 636_ NSILP 641_ PKKDL 646_ WTAPE 651_ HLRQA 656_ NISQK 661_ GDVYS 666_ YGIIA 671_ QEIIL 676_ RKETF 681_ YTLSC 686_ RDRNE 691_ KIFRV 696_ ENSNG 701_ MKPFR 706_ PDLFL 711_ ETAEE 716_ KELEV 721_ YLLVK 726_ NCWEE 731_ DPEKR 736_ PDFKK 741_ IETTL 746_ AKIFG 751_ LFHDQ 756_ KNESY 761_ MDTLI 766_ RRLQL 771_ YSRNL 776_ EHLVE 781_ ERTQL 786_ YKAER 791_ DRADR 796_ LNFML 801_ LPRLV 806_ VKSLK 811_ EKGFV 816_ EPELY 821_ EEVTI 826_ YFSDI 831_ VGFTT 836_ ICKYS 841_ TPMEV 846_ VDMLN 851_ DIYKS 856_ FDHIV 861_ DHHDV 866_ YKVET 871_ IGDAY 876_ MVASG 881_ LPKRN 886_ GNRHA 891_ IDIAK 896_ MALEI 901_ LSFMG 906_ TFELE 911_ HLPGL 916_ PIWIR 921_ IGVHS 926_ GPCAA 931_ GVVGI 936_ KMPRY 941_ CLFGD 946_ TVNTA 951_ SRMES 956_ TGLPL 961_ RIHVS 966_ GSTIA 971_ ILKRT 976_ ECQFL 981_ YEVRG 986_ ETYLK 991_ GRGNE 996_ TTYWL 1001_ TGMKD 1006_ QKFNL 1011_ PTPPT 1016_ VENQQ 1021_ RLQAE 1026_ FSDMI 1031_ ANSLQ 1036_ KRQAA 1041_ GIRSQ 1046_ KPRRV 1051_ ASYKK 1056_ GTLEY 1061_ LQLNT 1066_TDKES
1: Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596)