Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
1_MADLE 6_ AVLAD 11_ VSYLM 16_ AMEKS 21_ KATPA 26_ ARASK 31_ KILLP 36_ EPSIR 41_ SVMQK 46_ YLEDR 51_ GEVTF 56_ EKIFS 61_ QKLGY 66_ LLFRD 71_ FCLNH 76_ LEEAR 81_ PLVEF 86_ YEEIK 91_ KYEKL 96_ ETEEE 101_ RVARS 106_ REIFD 111_ SYIMK 116_ ELLAC 121_ SHPFS 126_ KSATE 131_ HVQGH 136_ LGKKQ 141_ VPPDL 146_ FQPYI 151_ EEICQ 156_ NLRGD 161_ VFQKF 166_ IESDK 171_ FTRFC 176_ QWKNV 181_ ELNIH 186_ LTMND 191_ FSVHR 196_ IIGRG 201_ GFGEV 206_ YGCRK 211_ ADTGK 216_ MYAMK 221_ CLDKK 226_ RIKMK 231_ QGETL 236_ ALNER 241_ IMLSL 246_ VSTGD 251_ CPFIV 256_ CMSYA 261_ FHTPD 266_ KLSFI 271_ LDLMN 276_ GGDLH 281_ YHLSQ 286_ HGVFS 291_ EADMR 296_ FYAAE 301_ IILGL 306_ EHMHN 311_ RFVVY 316_ RDLKP 321_ ANILL 326_ DEHGH 331_ VRISD 336_ LGLAC 341_ DFSKK 346_ KPHAS 351_ VGTHG 356_ YMAPE 361_ VLQKG 366_ VAYDS 371_ SADWF 376_ SLGCM 381_ LFKLL 386_ RGHSP 391_ FRQHK 396_ TKDKH 401_ EIDRM 406_ TLTMA 411_ VELPD 416_ SFSPE 421_ LRSLL 426_ EGLLQ 431_ RDVNR 436_ RLGCL 441_ GRGAQ 446_ EVKES 451_ PFFRS 456_ LDWQM 461_ VFLQK 466_ YPPPL 471_ IPPRG 476_ EVNAA 481_ DAFDI 486_ GSFDE 491_ EDTKG 496_ IKLLD 501_ SDQEL 506_ YRNFP 511_ LTISE 516_ RWQQE 521_ VAETV 526_ FDTIN 531_ AETDR 536_ LEARK 541_ KAKNK 546_ QLGHE 551_ EDYAL 556_ GKDCI 561_ MHGYM 566_ SKMGN 571_ PFLTQ 576_ WQRRY 581_ FYLFP 586_ NRLEW 591_ RGEGE 596_ APQSL 601_ LTMEE 606_ IQSVE 611_ ETQIK 616_ ERKCL 621_ LLKIR 626_ GGKQF 631_ ILQCD 636_ SDPEL 641_ VQWKK 646_ ELRDA 651_ YREAQ 656_ QLVQR 661_ VPKMK 666_ NKPRS 671_ PVVEL 676_ SKVPL 681_VQRGS
1: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927)