Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)
1_MDNVL 6_ PVDSD 11_ LSPNI 16_ STNTS 21_ EPNQF 26_ VQPAW 31_ QIVLW 36_ AAAYT 41_ VIVVT 46_ SVVGN 51_ VVVMW 56_ IILAH 61_ KRMRT 66_ VTNYF 71_ LVNLA 76_ FAEAS 81_ MAAFN 86_ TVVNF 91_ TYAVH 96_ NEWYY 101_ GLFYC 106_ KFHNF 111_ FPIAA 116_ VFASI 121_ YSMTA 126_ VAFDR 131_ YMAII 136_ HPLQP 141_ RLSAT 146_ ATKVV 151_ ICVIW 156_ VLALL 161_ LAFPQ 166_ GYYST 171_ TETMP 176_ SRVVC 181_ MIEWP 186_ EHPNK 191_ IYEKV 196_ YHICV 201_ TVLIY 206_ FLPLL 211_ VIGYA 216_ YTVVG 221_ ITLWA 226_ SEIPG 231_ DSSDR 236_ YHEQV 241_ SAKRK 246_ VVKMM 251_ IVVVC 256_ TFAIC 261_ WLPFH 266_ IFFLL 271_ PYINP 276_ DLYLK 281_ KFIQQ 286_ VYLAI 291_ MWLAM 296_ SSTMY 301_ NPIIY 306_ CCLND 311_ RFRLG 316_ FKHAF 321_ RCCPF 326_ ISAGD 331_ YEGLE 336_ MKSTR 341_ YLQTQ 346_ GSVYK 351_ VSRLE 356_ TTIST 361_ VVGAH 366_ EEEPE 371_ DGPKA 376_ TPSSL 381_ DLTSN 386_ CSSRS 391_ DSKTM 396_ TESFS 401_FSSNV
1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K