Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
1_MGPRR 6_ LLLVA 11_ ACFSL 16_ CGPLL 21_ SARTR 26_ ARRPE 31_ SKATN 36_ ATLDP 41_ RSFLL 46_ RNPND 51_ KYEPF 56_ WEDEE 61_ KNESG 66_ LTEYR 71_ LVSIN 76_ KSSPL 81_ QKQLP 86_ AFISE 91_ DASGY 96_ LTSSW 101_ LTLFV 106_ PSVYT 111_ GVFVV 116_ SLPLN 121_ IMAIV 126_ VFILK 131_ MKVKK 136_ PAVVY 141_ MLHLA 146_ TADVL 151_ FVSVL 156_ PFKIS 161_ YYFSG 166_ SDWQF 171_ GSELC 176_ RFVTA 181_ AFYCN 186_ MYASI 191_ LLMTV 196_ ISIDR 201_ FLAVV 206_ YPMQS 211_ LSWRT 216_ LGRAS 221_ FTCLA 226_ IWALA 231_ IAGVV 236_ PLLLK 241_ EQTIQ 246_ VPGLN 251_ ITTCH 256_ DVLNE 261_ TLLEG 266_ YYAYY 271_ FSAFS 276_ AVFFF 281_ VPLII 286_ STVCY 291_ VSIIR 296_ CLSSS 301_ AVANR 306_ SKKSR 311_ ALFLS 316_ AAVFC 321_ IFIIC 326_ FGPTN 331_ VLLIA 336_ HYSFL 341_ SHTST 346_ TEAAY 351_ FAYLL 356_ CVCVS 361_ SISCC 366_ IDPLI 371_ YYYAS 376_ SECQR 381_ YVYSI 386_ LCCKE 391_ SSDPS 396_ SYNSS 401_ GQLMA 406_ SKMDT 411_ CSSNL 416_NNSIY
1: High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (PubMed:10079109). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed:30568593, PubMed:34831181)