DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
1_MAGTV 6_ VLDDV 11_ ELREA 16_ QRDYL 21_ DFLDD 26_ EEDQG 31_ IYQSK 36_ VRELI 41_ SDNQY 46_ RLIVN 51_ VNDLR 56_ RKNEK 61_ RANRL 66_ LNNAF 71_ EELVA 76_ FQRAL 81_ KDFVA 86_ SIDAT 91_ YAKQY 96_ EEFYV 101_ GLEGS 106_ FGSKH 111_ VSPRT 116_ LTSCF 121_ LSCVV 126_ CVEGI 131_ VTKCS 136_ LVRPK 141_ VVRSV 146_ HYCPA 151_ TKKTI 156_ ERRYS 161_ DLTTL 166_ VAFPS 171_ SSVYP 176_ TKDEE 181_ NNPLE 186_ TEYGL 191_ SVYKD 196_ HQTIT 201_ IQEMP 206_ EKAPA 211_ GQLPR 216_ SVDVI 221_ LDDDL 226_ VDKAK 231_ PGDRV 236_ QVVGT 241_ YRCLP 246_ GKKGG 251_ YTSGT 256_ FRTVL 261_ IACNV 266_ KQMSK 271_ DAQPS 276_ FSAED 281_ IAKIK 286_ KFSKT 291_ RSKDI 296_ FDQLA 301_ KSLAP 306_ SIHGH 311_ DYVKK 316_ AILCL 321_ LLGGV 326_ ERDLE 331_ NGSHI 336_ RGDIN 341_ ILLIG 346_ DPSVA 351_ KSQLL 356_ RYVLC 361_ TAPRA 366_ IPTTG 371_ RGSSG 376_ VGLTA 381_ AVTTD 386_ QETGE 391_ RRLEA 396_ GAMVL 401_ ADRGV 406_ VCIDE 411_ FDKMS 416_ DMDRT 421_ AIHEV 426_ MEQGR 431_ VTIAK 436_ AGIHA 441_ RLNAR 446_ CSVLA 451_ AANPV 456_ YGRYD 461_ QYKTP 466_ MENIG 471_ LQDSL 476_ LSRFD 481_ LLFIM 486_ LDQMD 491_ PEQDR 496_ EISDH 501_ VLRMH 506_ RYRAP 511_ GEQDG 516_ DAMPL 521_ GSAVD 526_ ILATD 531_ DPNFS 536_ QEDQQ 541_ DTQIY 546_ EKHDN 551_ LLHGT 556_ KKKKE 561_ KMVSA 566_ AFMKK 571_ YIHVA 576_ KIIKP 581_ VLTQE 586_ SATYI 591_ AEEYS 596_ RLRSQ 601_ DSMSS 606_ DTART 611_ SPVTA 616_ RTLET 621_ LIRLA 626_ TAHAK 631_ ARMSK 636_ TVDLQ 641_ DAEEA 646_ VELVQ 651_ YAYFK 656_ KVLEK 661_ EKKRK 666_ KRSED 671_ ESETE 676_ DEEEK 681_ SQEDQ 686_ EQKRK 691_ RRKTR 696_ QPDAK 701_ DGDSY 706_ DPYDF 711_ SDTEE 716_ EMPQV 721_ HTPKT 726_ ADSQE 731_ TKESQ 736_ KVELS 741_ ESRLK 746_ AFKVA 751_ LLDVF 756_ REAHA 761_ QSIGM 766_ NRLTE 771_ SINRD 776_ SEEPF 781_ SSVEI 786_ QAALS 791_ KMQDD 796_ NQVMV 801_SEGII
1: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable)