Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein)
1_MLQNV 6_ TPHNK 11_ LPGEG 16_ NAGLL 21_ GLGPE 26_ AAAPG 31_ KRIRK 36_ PSLLY 41_ EGFES 46_ PTMAS 51_ VPALQ 56_ LTPAN 61_ PPPPE 66_ VSNPK 71_ KPGRV 76_ TNQLQ 81_ YLHKV 86_ VMKAL 91_ WKHQF 96_ AWPFR 101_ QPVDA 106_ VKLGL 111_ PDYHK 116_ IIKQP 121_ MDMGT 126_ IKRRL 131_ ENNYY 136_ WAASE 141_ CMQDF 146_ NTMFT 151_ NCYIY 156_ NKPTD 161_ DIVLM 166_ AQTLE 171_ KIFLQ 176_ KVASM 181_ PQEEQ 186_ ELVVT 191_ IPKNS 196_ HKKGA 201_ KLAAL 206_ QGSVT 211_ SAHQV 216_ PAVSS 221_ VSHTA 226_ LYTPP 231_ PEIPT 236_ TVLNI 241_ PHPSV 246_ ISSPL 251_ LKSLH 256_ SAGPP 261_ LLAVT 266_ AAPPA 271_ QPLAK 276_ KKGVK 281_ RKADT 286_ TTPTP 291_ TAILA 296_ PGSPA 301_ SPPGS 306_ LEPKA 311_ ARLPP 316_ MRRES 321_ GRPIK 326_ PPRKD 331_ LPDSQ 336_ QQHQS 341_ SKKGK 346_ LSEQL 351_ KHCNG 356_ ILKEL 361_ LSKKH 366_ AAYAW 371_ PFYKP 376_ VDASA 381_ LGLHD 386_ YHDII 391_ KHPMD 396_ LSTVK 401_ RKMEN 406_ RDYRD 411_ AQEFA 416_ ADVRL 421_ MFSNC 426_ YKYNP 431_ PDHDV 436_ VAMAR 441_ KLQDV 446_ FEFRY 451_ AKMPD 456_ EPLEP 461_ GPLPV 466_ STAMP 471_ PGLAK 476_ SSSES 481_ SSEES 486_ SSESS 491_ SEEEE 496_ EEDEE 501_ DEEEE 506_ ESESS 511_ DSEEE 516_ RAHRL 521_ AELQE 526_ QLRAV 531_ HEQLA 536_ ALSQG 541_ PISKP 546_ KRKRE 551_ KKEKK 556_ KKRKA 561_ EKHRG 566_ RAGAD 571_ EDDKG 576_ PRAPR 581_ PPQPK 586_ KSKKA 591_ SGSGG 596_ GSAAL 601_ GPSGF 606_ GPSGG 611_ SGTKL 616_ PKKAT 621_ KTAPP 626_ ALPTG 631_ YDSEE 636_ EEESR 641_ PMSYD 646_ EKRQL 651_ SLDIN 656_ KLPGE 661_ KLGRV 666_ VHIIQ 671_ AREPS 676_ LRDSN 681_ PEEIE 686_ IDFET 691_ LKPST 696_ LRELE 701_ RYVLS 706_ CLRKK 711_ PRKPY 716_ TIKKP 721_ VGKTK 726_ EELAL 731_ EKKRE 736_ LEKRL 741_ QDVSG 746_ QLNST 751_ KKPPK 756_ KANEK 761_ TESSS 766_ AQQVA 771_ VSRLS 776_ ASSSS 781_ SDSSS 786_ SSSSS 791_ SSSDT 796_SDSDS
1: Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000)