Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
1_MLGIW 6_ TLLPL 11_ VLTSV 16_ ARLSS 21_ KSVNA 26_ QVTDI 31_ NSKGL 36_ ELRKT 41_ VTTVE 46_ TQNLE 51_ GLHHD 56_ GQFCH 61_ KPCPP 66_ GERKA 71_ RDCTV 76_ NGDEP 81_ DCVPC 86_ QEGKE 91_ YTDKA 96_ HFSSK 101_ CRRCR 106_ LCDEG 111_ HGLEV 116_ EINCT 121_ RTQNT 126_ KCRCK 131_ PNFFC 136_ NSTVC 141_ EHCDP 146_ CTKCE 151_ HGIIK 156_ ECTLT 161_ SNTKC 166_ KEEGS 171_ RSNLG 176_ WLCLL 181_ LLPIP 186_ LIVWV 191_ KRKEV 196_ QKTCR 201_ KHRKE 206_ NQGSH 211_ ESPTL 216_ NPETV 221_ AINLS 226_ DVDLS 231_ KYITT 236_ IAGVM 241_ TLSQV 246_ KGFVR 251_ KNGVN 256_ EAKID 261_ EIKND 266_ NVQDT 271_ AEQKV 276_ QLLRN 281_ WHQLH 286_ GKKEA 291_ YDTLI 296_ KDLKK 301_ ANLCT 306_ LAEKI 311_ QTIIL 316_ KDITS 321_ DSENS 326_NFRNE
1: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)