Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)
1_MASGD 6_ TLYIA 11_ TDGSE 16_ MPAEI 21_ VELHE 26_ IEVET 31_ IPVET 36_ IETTV 41_ VGEEE 46_ EEDDD 51_ DEDGG 56_ GGDHG 61_ GGGGH 66_ GHAGH 71_ HHHHH 76_ HHHHH 81_ PPMIA 86_ LQPLV 91_ TDDPT 96_ QVHHH 101_ QEVIL 106_ VQTRE 111_ EVVGG 116_ DDSDG 121_ LRAED 126_ GFEDQ 131_ ILIPV 136_ PAPAG 141_ GDDDY 146_ IEQTL 151_ VTVAA 156_ AGKSG 161_ GGGSS 166_ SSGGG 171_ RVKKG 176_ GGKKS 181_ GKKSY 186_ LSGGA 191_ GAAGG 196_ GGADP 201_ GNKKW 206_ EQKQV 211_ QIKTL 216_ EGEFS 221_ VTMWS 226_ SDEKK 231_ DIDHE 236_ TVVEE 241_ QIIGE 246_ NSPPD 251_ YSEYM 256_ TGKKL 261_ PPGGI 266_ PGIDL 271_ SDPKQ 276_ LAEFA 281_ RMKPR 286_ KIKED 291_ DAPRT 296_ IACPH 301_ KGCTK 306_ MFRDN 311_ SAMRK 316_ HLHTH 321_ GPRVH 326_ VCAEC 331_ GKAFV 336_ ESSKL 341_ KRHQL 346_ VHTGE 351_ KPFQC 356_ TFEGC 361_ GKRFS 366_ LDFNL 371_ RTHVR 376_ IHTGD 381_ RPYVC 386_ PFDGC 391_ NKKFA 396_ QSTNL 401_ KSHIL 406_THAKA
1: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357)
2: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements