DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)
1_MASYY 6_ EILDV 11_ PRSAS 16_ ADDIK 21_ KAYRR 26_ KALQW 31_ HPDKN 36_ PDNKE 41_ FAEKK 46_ FKEVA 51_ EAYEV 56_ LSDKH 61_ KREIY 66_ DRYGR 71_ EGLTG 76_ TGTGP 81_ SRAEA 86_ GSGGP 91_ GFTFT 96_ FRSPE 101_ EVFRE 106_ FFGSG 111_ DPFAE 116_ LFDDL 121_ GPFSE 126_ LQNRG 131_ SRHSG 136_ PFFTF 141_ SSSFP 146_ GHSDF 151_ SSSSF 156_ SFSPG 161_ AGAFR 166_ SVSTS 171_ TTFVQ 176_ GRRIT 181_ TRRIM 186_ ENGQE 191_ RVEVE 196_ EDGQL 201_ KSVTI 206_ NGVPD 211_ DLALG 216_ LELSR 221_ REQQP 226_ SVTSR 231_ SGGTQ 236_ VQQTP 241_ ASCPL 246_ DSDLS 251_ EDEDL 256_ QLAMA 261_ YSLSE 266_ MEAAG 271_ KKPAG 276_ GREAQ 281_ HRRQG 286_ RPKAQ 291_ HQDPG 296_ LGGTQ 301_ EGARG 306_ EATKR 311_ SPSPE 316_EKASR
1: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278)