Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
1_MFRNQ 6_ YDNDV 11_ TVWSP 16_ QGRIH 21_ QIEYA 26_ MEAVK 31_ QGSAT 36_ VGLKS 41_ KTHAV 46_ LVALK 51_ RAQSE 56_ LAAHQ 61_ KKILH 66_ VDNHI 71_ GISIA 76_ GLTAD 81_ ARLLC 86_ NFMRQ 91_ ECLDS 96_ RFVFD 101_ RPLPV 106_ SRLVS 111_ LIGSK 116_ TQIPT 121_ QRYGR 126_ RPYGV 131_ GLLIA 136_ GYDDM 141_ GPHIF 146_ QTCPS 151_ ANYFD 156_ CRAMS 161_ IGARS 166_ QSART 171_ YLERH 176_ MSEFM 181_ ECNLN 186_ ELVKH 191_ GLRAL 196_ RETLP 201_ AEQDL 206_ TTKNV 211_ SIGIV 216_ GKDLE 221_ FTIYD 226_ DDDVS 231_ PFLEG 236_ LEERP 241_ QRKAQ 246_ PAQPA 251_ DEPAE 256_KADEP
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)