Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)
1_MAERG 6_ YSFSL 11_ TTFSP 16_ SGKLV 21_ QIEYA 26_ LAAVA 31_ GGAPS 36_ VGIKA 41_ ANGVV 46_ LATEK 51_ KQKSI 56_ LYDER 61_ SVHKV 66_ EPITK 71_ HIGLV 76_ YSGMG 81_ PDYRV 86_ LVHRA 91_ RKLAQ 96_ QYYLV 101_ YQEPI 106_ PTAQL 111_ VQRVA 116_ SVMQE 121_ YTQSG 126_ GVRPF 131_ GVSLL 136_ ICGWN 141_ EGRPY 146_ LFQSD 151_ PSGAY 156_ FAWKA 161_ TAMGK 166_ NYVNG 171_ KTFLE 176_ KRYNE 181_ DLELE 186_ DAIHT 191_ AILTL 196_ KESFE 201_ GQMTE 206_ DNIEV 211_ GICNE 216_ AGFRR 221_ LTPTE 226_VKDYL
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)