Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
1_MSSIG 6_ TGYDL 11_ SASTF 16_ SPDGR 21_ VFQVE 26_ YAMKA 31_ VENSS 36_ TAIGI 41_ RCKDG 46_ VVFGV 51_ EKLVL 56_ SKLYE 61_ EGSNK 66_ RLFNV 71_ DRHVG 76_ MAVAG 81_ LLADA 86_ RSLAD 91_ IAREE 96_ ASNFR 101_ SNFGY 106_ NIPLK 111_ HLADR 116_ VAMYV 121_ HAYTL 126_ YSAVR 131_ PFGCS 136_ FMLGS 141_ YSVND 146_ GAQLY 151_ MIDPS 156_ GVSYG 161_ YWGCA 166_ IGKAR 171_ QAAKT 176_ EIEKL 181_ QMKEM 186_ TCRDI 191_ VKEVA 196_ KIIYI 201_ VHDEV 206_ KDKAF 211_ ELELS 216_ WVGEL 221_ TNGRH 226_ EIVPK 231_ DIREE 236_ AEKYA 241_ KESLK 246_EEDES
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2