Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)
1_MSRRY 6_ DSRTT 11_ IFSPE 16_ GRLYQ 21_ VEYAM 26_ EAIGH 31_ AGTCL 36_ GILAN 41_ DGVLL 46_ AAERR 51_ NIHKL 56_ LDEVF 61_ FSEKI 66_ YKLNE 71_ DMACS 76_ VAGIT 81_ SDANV 86_ LTNEL 91_ RLIAQ 96_ RYLLQ 101_ YQEPI 106_ PCEQL 111_ VTALC 116_ DIKQA 121_ YTQFG 126_ GKRPF 131_ GVSLL 136_ YIGWD 141_ KHYGF 146_ QLYQS 151_ DPSGN 156_ YGGWK 161_ ATCIG 166_ NNSAA 171_ AVSML 176_ KQDYK 181_ EGEMT 186_ LKSAL 191_ ALAIK 196_ VLNKT 201_ MDVSK 206_ LSAEK 211_ VEIAT 216_ LTREN 221_ GKTVI 226_ RVLKQ 231_ KEVEQ 236_ LIKKH 241_ EEEEA 246_ KAERE 251_ KKEKE 256_QKEKD
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)