Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin)
1_MGGLT 6_ ASDVH 11_ PTLGV 16_ QLFSA 21_ GIAAC 26_ LADVI 31_ TFPLD 36_ TAKVR 41_ LQVQG 46_ ECPTS 51_ SVIRY 56_ KGVLG 61_ TITAV 66_ VKTEG 71_ RMKLY 76_ SGLPA 81_ GLQRQ 86_ ISSAS 91_ LRIGL 96_ YDTVQ 101_ EFLTA 106_ GKETA 111_ PSLGS 116_ KILAG 121_ LTTGG 126_ VAVFI 131_ GQPTE 136_ VVKVR 141_ LQAQS 146_ HLHGI 151_ KPRYT 156_ GTYNA 161_ YRIIA 166_ TTEGL 171_ TGLWK 176_ GTTPN 181_ LMRSV 186_ IINCT 191_ ELVTY 196_ DLMKE 201_ AFVKN 206_ NILAD 211_ DVPCH 216_ LVSAL 221_ IAGFC 226_ ATAMS 231_ SPVDV 236_ VKTRF 241_ INSPP 246_ GQYKS 251_ VPNCA 256_ MKVFT 261_ NEGPT 266_ AFFKG 271_ LVPSF 276_ LRLGS 281_ WNVIM 286_ FVCFE 291_ QLKRE 296_ LSKSR 301_QTMDC
1: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960, PubMed:28781081). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity)