NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
1_MFQAA 6_ ERPQE 11_ WAMEG 16_ PRDGL 21_ KKERL 26_ LDDRH 31_ DSGLD 36_ SMKDE 41_ EYEQM 46_ VKELQ 51_ EIRLE 56_ PQEVP 61_ RGSEP 66_ WKQQL 71_ TEDGD 76_ SFLHL 81_ AIIHE 86_ EKALT 91_ MEVIR 96_ QVKGD 101_ LAFLN 106_ FQNNL 111_ QQTPL 116_ HLAVI 121_ TNQPE 126_ IAEAL 131_ LGAGC 136_ DPELR 141_ DFRGN 146_ TPLHL 151_ ACEQG 156_ CLASV 161_ GVLTQ 166_ SCTTP 171_ HLHSI 176_ LKATN 181_ YNGHT 186_ CLHLA 191_ SIHGY 196_ LGIVE 201_ LLVSL 206_ GADVN 211_ AQEPC 216_ NGRTA 221_ LHLAV 226_ DLQNP 231_ DLVSL 236_ LLKCG 241_ ADVNR 246_ VTYQG 251_ YSPYQ 256_ LTWGR 261_ PSTRI 266_ QQQLG 271_ QLTLE 276_ NLQML 281_ PESED 286_ EESYD 291_ TESEF 296_ TEFTE 301_ DELPY 306_ DDCVF 311_GGQRL
1: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466)