Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
1_MGPGP 6_ SRAPR 11_ APRLM 16_ LCALA 21_ LMVAA 26_ GGCVV 31_ SAFNL 36_ DTRFL 41_ VVKEA 46_ GNPGS 51_ LFGYS 56_ VALHR 61_ QTERQ 66_ QRYLL 71_ LAGAP 76_ RELAV 81_ PDGYT 86_ NRTGA 91_ VYLCP 96_ LTAHK 101_ DDCER 106_ MNITV 111_ KNDPG 116_ HHIIE 121_ DMWLG 126_ VTVAS 131_ QGPAG 136_ RVLVC 141_ AHRYT 146_ QVLWS 151_ GSEDQ 156_ RRMVG 161_ KCYVR 166_ GNDLE 171_ LDSSD 176_ DWQTY 181_ HNEMC 186_ NSNTD 191_ YLETG 196_ MCQLG 201_ TSGGF 206_ TQNTV 211_ YFGAP 216_ GAYNW 221_ KGNSY 226_ MIQRK 231_ EWDLS 236_ EYSYK 241_ DPEDQ 246_ GNLYI 251_ GYTMQ 256_ VGSFI 261_ LHPKN 266_ ITIVT 271_ GAPRH 276_ RHMGA 281_ VFLLS 286_ QEAGG 291_ DLRRR 296_ QVLEG 301_ SQVGA 306_ YFGSA 311_ IALAD 316_ LNNDG 321_ WQDLL 326_ VGAPY 331_ YFERK 336_ EEVGG 341_ AIYVF 346_ MNQAG 351_ TSFPA 356_ HPSLL 361_ LHGPS 366_ GSAFG 371_ LSVAS 376_ IGDIN 381_ QDGFQ 386_ DIAVG 391_ APFEG 396_ LGKVY 401_ IYHSS 406_ SKGLL 411_ RQPQQ 416_ VIHGE 421_ KLGLP 426_ GLATF 431_ GYSLS 436_ GQMDV 441_ DENFY 446_ PDLLV 451_ GSLSD 456_ HIVLL 461_ RARPV 466_ INIVH 471_ KTLVP 476_ RPAVL 481_ DPALC 486_ TATSC 491_ VQVEL 496_ CFAYN 501_ QSAGN 506_ PNYRR 511_ NITLA 516_ YTLEA 521_ DRDRR 526_ PPRLR 531_ FAGSE 536_ SAVFH 541_ GFFSM 546_ PEMRC 551_ QKLEL 556_ LLMDN 561_ LRDKL 566_ RPIII 571_ SMNYS 576_ LPLRM 581_ PDRPR 586_ LGLRS 591_ LDAYP 596_ ILNQA 601_ QALEN 606_ HTEVQ 611_ FQKEC 616_ GPDNK 621_ CESNL 626_ QMRAA 631_ FVSEQ 636_ QQKLS 641_ RLQYS 646_ RDVRK 651_ LLLSI 656_ NVTNT 661_ RTSER 666_ SGEDA 671_ HEALL 676_ TLVVP 681_ PALLL 686_ SSVRP 691_ PGACQ 696_ ANETI 701_ FCELG 706_ NPFKR 711_ NQRME 716_ LLIAF 721_ EVIGV 726_ TLHTR 731_ DLQVQ 736_ LQLST 741_ SSHQD 746_ NLWPM 751_ ILTLL 756_ VDYTL 761_ QTSLS 766_ MVNHR 771_ LQSFF 776_ GGTVM 781_ GESGM 786_ KTVED 791_ VGSPL 796_ KYEFQ 801_ VGPMG 806_ EGLVG 811_ LGTLV 816_ LGLEW 821_ PYEVS 826_ NGKWL 831_ LYPTE 836_ ITVHG 841_ NGSWP 846_ CRPPG 851_ DLINP 856_ LNLTL 861_ SDPGD 866_ RPSSP 871_ QRRRR 876_ QLDPG 881_ GGQGP 886_ PPVTL 891_ AAAKK 896_ AKSET 901_ VLTCA 906_ TGRAH 911_ CVWLE 916_ CPIPD 921_ APVVT 926_ NVTVK 931_ ARVWN 936_ STFIE 941_ DYRDF 946_ DRVRV 951_ NGWAT 956_ LFLRT 961_ SIPTI 966_ NMENK 971_ TTWFS 976_ VDIDS 981_ ELVEE 986_ LPAEI 991_ ELWLV 996_ LVAVG 1001_ AGLLL 1006_ LGLII 1011_ LLLWK 1016_ CGFFK 1021_ RARTR 1026_ ALYEA 1031_ KRQKA 1036_ EMKSQ 1041_ PSETE 1046_RLTDD
1: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration
2: (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression