Integrin beta-7 (Gut homing receptor beta subunit)
1_MVALP 6_ MVLVL 11_ LLVLS 16_ RGESE 21_ LDAKI 26_ PSTGD 31_ ATEWR 36_ NPHLS 41_ MLGSC 46_ QPAPS 51_ CQKCI 56_ LSHPS 61_ CAWCK 66_ QLNFT 71_ ASGEA 76_ EARRC 81_ ARREE 86_ LLARG 91_ CPLEE 96_ LEEPR 101_ GQQEV 106_ LQDQP 111_ LSQGA 116_ RGEGA 121_ TQLAP 126_ QRVRV 131_ TLRPG 136_ EPQQL 141_ QVRFL 146_ RAEGY 151_ PVDLY 156_ YLMDL 161_ SYSMK 166_ DDLER 171_ VRQLG 176_ HALLV 181_ RLQEV 186_ THSVR 191_ IGFGS 196_ FVDKT 201_ VLPFV 206_ STVPS 211_ KLRHP 216_ CPTRL 221_ ERCQS 226_ PFSFH 231_ HVLSL 236_ TGDAQ 241_ AFERE 246_ VGRQS 251_ VSGNL 256_ DSPEG 261_ GFDAI 266_ LQAAL 271_ CQEQI 276_ GWRNV 281_ SRLLV 286_ FTSDD 291_ TFHTA 296_ GDGKL 301_ GGIFM 306_ PSDGH 311_ CHLDS 316_ NGLYS 321_ RSTEF 326_ DYPSV 331_ GQVAQ 336_ ALSAA 341_ NIQPI 346_ FAVTS 351_ AALPV 356_ YQELS 361_ KLIPK 366_ SAVGE 371_ LSEDS 376_ SNVVQ 381_ LIMDA 386_ YNSLS 391_ STVTL 396_ EHSSL 401_ PPGVH 406_ ISYES 411_ QCEGP 416_ EKREG 421_ KAEDR 426_ GQCNH 431_ VRINQ 436_ TVTFW 441_ VSLQA 446_ THCLP 451_ EPHLL 456_ RLRAL 461_ GFSEE 466_ LIVEL 471_ HTLCD 476_ CNCSD 481_ TQPQA 486_ PHCSD 491_ GQGHL 496_ QCGVC 501_ SCAPG 506_ RLGRL 511_ CECSV 516_ AELSS 521_ PDLES 526_ GCRAP 531_ NGTGP 536_ LCSGK 541_ GHCQC 546_ GRCSC 551_ SGQSS 556_ GHLCE 561_ CDDAS 566_ CERHE 571_ GILCG 576_ GFGRC 581_ QCGVC 586_ HCHAN 591_ RTGRA 596_ CECSG 601_ DMDSC 606_ ISPEG 611_ GLCSG 616_ HGRCK 621_ CNRCQ 626_ CLDGY 631_ YGALC 636_ DQCPG 641_ CKTPC 646_ ERHRD 651_ CAECG 656_ AFRTG 661_ PLATN 666_ CSTAC 671_ AHTNV 676_ TLALA 681_ PILDD 686_ GWCKE 691_ RTLDN 696_ QLFFF 701_ LVEDD 706_ ARGTV 711_ VLRVR 716_ PQEKG 721_ ADHTQ 726_ AIVLG 731_ CVGGI 736_ VAVGL 741_ GLVLA 746_ YRLSV 751_ EIYDR 756_ REYSR 761_ FEKEQ 766_ QQLNW 771_ KQDSN 776_ PLYKS 781_ AITTT 786_ INPRF 791_QEADS
1: Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract (PubMed:10837471, PubMed:14608374). Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin (PubMed:10837471)
2: (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120