Integrin beta-8
1_MCGSA 6_ LAFFT 11_ AAFVC 16_ LQNDR 21_ RGPAS 26_ FLWAA 31_ WVFSL 36_ VLGLG 41_ QGEDN 46_ RCASS 51_ NAASC 56_ ARCLA 61_ LGPEC 66_ GWCVQ 71_ EDFIS 76_ GGSRS 81_ ERCDI 86_ VSNLI 91_ SKGCS 96_ VDSIE 101_ YPSVH 106_ VIIPT 111_ ENEIN 116_ TQVTP 121_ GEVSI 126_ QLRPG 131_ AEANF 136_ MLKVH 141_ PLKKY 146_ PVDLY 151_ YLVDV 156_ SASMH 161_ NNIEK 166_ LNSVG 171_ NDLSR 176_ KMAFF 181_ SRDFR 186_ LGFGS 191_ YVDKT 196_ VSPYI 201_ SIHPE 206_ RIHNQ 211_ CSDYN 216_ LDCMP 221_ PHGYI 226_ HVLSL 231_ TENIT 236_ EFEKA 241_ VHRQK 246_ ISGNI 251_ DTPEG 256_ GFDAM 261_ LQAAV 266_ CESHI 271_ GWRKE 276_ AKRLL 281_ LVMTD 286_ QTSHL 291_ ALDSK 296_ LAGIV 301_ VPNDG 306_ NCHLK 311_ NNVYV 316_ KSTTM 321_ EHPSL 326_ GQLSE 331_ KLIDN 336_ NINVI 341_ FAVQG 346_ KQFHW 351_ YKDLL 356_ PLLPG 361_ TIAGE 366_ IESKA 371_ ANLNN 376_ LVVEA 381_ YQKLI 386_ SEVKV 391_ QVENQ 396_ VQGIY 401_ FNITA 406_ ICPDG 411_ SRKPG 416_ MEGCR 421_ NVTSN 426_ DEVLF 431_ NVTVT 436_ MKKCD 441_ VTGGK 446_ NYAII 451_ KPIGF 456_ NETAK 461_ IHIHR 466_ NCSCQ 471_ CEDNR 476_ GPKGK 481_ CVDET 486_ FLDSK 491_ CFQCD 496_ ENKCH 501_ FDEDQ 506_ FSSES 511_ CKSHK 516_ DQPVC 521_ SGRGV 526_ CVCGK 531_ CSCHK 536_ IKLGK 541_ VYGKY 546_ CEKDD 551_ FSCPY 556_ HHGNL 561_ CAGHG 566_ ECEAG 571_ RCQCF 576_ SGWEG 581_ DRCQC 586_ PSAAA 591_ QHCVN 596_ SKGQV 601_ CSGRG 606_ TCVCG 611_ RCECT 616_ DPRSI 621_ GRFCE 626_ HCPTC 631_ YTACK 636_ ENWNC 641_ MQCLH 646_ PHNLS 651_ QAILD 656_ QCKTS 661_ CALME 666_ QQHYV 671_ DQTSE 676_ CFSSP 681_ SYLRI 686_ FFIIF 691_ IVTFL 696_ IGLLK 701_ VLIIR 706_ QVILQ 711_ WNSNK 716_ IKSSS 721_ DYRVS 726_ ASKKD 731_ KLILQ 736_ SVCTR 741_ AVTYR 746_ REKPE 751_ EIKMD 756_ ISKLN 761_AHETF
1: Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity)