Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)
1_MSTAR 6_ TENPV 11_ IMGLS 16_ SQNGQ 21_ LRGPV 26_ KPTGG 31_ PGGGG 36_ TQTQQ 41_ QMNQL 46_ KNTNT 51_ INNGT 56_ QQQAQ 61_ SMTTT 66_ IKPGD 71_ DWKKT 76_ LKLPP 81_ KDLRI 86_ KTSDV 91_ TSTKG 96_ NEFED 101_ YCLKR 106_ ELLMG 111_ IFEMG 116_ WEKPS 121_ PIQEE 126_ SIPIA 131_ LSGRD 136_ ILARA 141_ KNGTG 146_ KSGAY 151_ LIPLL 156_ ERLDL 161_ KKDNI 166_ QAMVI 171_ VPTRE 176_ LALQV 181_ SQICI 186_ QVSKH 191_ MGGAK 196_ VMATT 201_ GGTNL 206_ RDDIM 211_ RLDDT 216_ VHVVI 221_ ATPGR 226_ ILDLI 231_ KKGVA 236_ KVDHV 241_ QMIVL 246_ DEADK 251_ LLSQD 256_ FVQIM 261_ EDIIL 266_ TLPKN 271_ RQILL 276_ YSATF 281_ PLSVQ 286_ KFMNS 291_ HLQKP 296_ YEINL 301_ MEELT 306_ LKGVT 311_ QYYAY 316_ VTERQ 321_ KVHCL 326_ NTLFS 331_ RLQIN 336_ QSIIF 341_ CNSSQ 346_ RVELL 351_ AKKIS 356_ QLGYS 361_ CFYIH 366_ AKMRQ 371_ EHRNR 376_ VFHDF 381_ RNGLC 386_ RNLVC 391_ TDLFT 396_ RGIDI 401_ QAVNV 406_ VINFD 411_ FPKLA 416_ ETYLH 421_ RIGRS 426_ GRFGH 431_ LGLAI 436_ NLITY 441_ DDRFN 446_ LKSIE 451_ EQLGT 456_ EIKPI 461_ PSNID 466_ KSLYV 471_ AEYHS 476_EPVED
1: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573)