DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
1_MPART 6_ APARV 11_ PTLAV 16_ PAISL 21_ PDDVR 26_ RRLKD 31_ LERDS 36_ LTEKE 41_ CVKEK 46_ LNLLH 51_ EFLQT 56_ EIKNQ 61_ LCDLE 66_ TKLRK 71_ EELSE 76_ EGYLA 81_ KVKSL 86_ LNKDL 91_ SLENG 96_ AHAYN 101_ REVNG 106_ RLENG 111_ NQARS 116_ EARRV 121_ GMADA 126_ NSPPK 131_ PLSKP 136_ RTPRR 141_ SKSDG 146_ EAKPE 151_ PSPSP 156_ RITRK 161_ STRQT 166_ TITSH 171_ FAKGP 176_ AKRKP 181_ QEESE 186_ RAKSD 191_ ESIKE 196_ EDKDQ 201_ DEKRR 206_ RVTSR 211_ ERVAR 216_ PLPAE 221_ EPERA 226_ KSGTR 231_ TEKEE 236_ ERDEK 241_ EEKRL 246_ RSQTK 251_ EPTPK 256_ QKLKE 261_ EPDRE 266_ ARAGV 271_ QADED 276_ EDGDE 281_ KDEKK 286_ HRSQP 291_ KDLAA 296_ KRRPE 301_ EKEPE 306_ KVNPQ 311_ ISDEK 316_ DEDEK 321_ EEKRR 326_ KTTPK 331_ EPTEK 336_ KMARA 341_ KTVMN 346_ SKTHP 351_ PKCIQ 356_ CGQYL 361_ DDPDL 366_ KYGQH 371_ PPDAV 376_ DEPQM 381_ LTNEK 386_ LSIFD 391_ ANESG 396_ FESYE 401_ ALPQH 406_ KLTCF 411_ SVYCK 416_ HGHLC 421_ PIDTG 426_ LIEKN 431_ IELFF 436_ SGSAK 441_ PIYDD 446_ DPSLE 451_ GGVNG 456_ KNLGP 461_ INEWW 466_ ITGFD 471_ GGEKA 476_ LIGFS 481_ TSFAE 486_ YILMD 491_ PSPEY 496_ APIFG 501_ LMQEK 506_ IYISK 511_ IVVEF 516_ LQSNS 521_ DSTYE 526_ DLINK 531_ IETTV 536_ PPSGL 541_ NLNRF 546_ TEDSL 551_ LRHAQ 556_ FVVEQ 561_ VESYD 566_ EAGDS 571_ DEQPI 576_ FLTPC 581_ MRDLI 586_ KLAGV 591_ TLGQR 596_ RAQAR 601_ RQTIR 606_ HSTRE 611_ KDRGP 616_ TKATT 621_ TKLVY 626_ QIFDT 631_ FFAEQ 636_ IEKDD 641_ REDKE 646_ NAFKR 651_ RRCGV 656_ CEVCQ 661_ QPECG 666_ KCKAC 671_ KDMVK 676_ FGGSG 681_ RSKQA 686_ CQERR 691_ CPNMA 696_ MKEAD 701_ DDEEV 706_ DDNIP 711_ EMPSP 716_ KKMHQ 721_ GKKKK 726_ QNKNR 731_ ISWVG 736_ EAVKT 741_ DGKKS 746_ YYKKV 751_ CIDAE 756_ TLEVG 761_ DCVSV 766_ IPDDS 771_ SKPLY 776_ LARVT 781_ ALWED 786_ SSNGQ 791_ MFHAH 796_ WFCAG 801_ TDTVL 806_ GATSD 811_ PLELF 816_ LVDEC 821_ EDMQL 826_ SYIHS 831_ KVKVI 836_ YKAPS 841_ ENWAM 846_ EGGMD 851_ PESLL 856_ EGDDG 861_ KTYFY 866_ QLWYD 871_ QDYAR 876_ FESPP 881_ KTQPT 886_ EDNKF 891_ KFCVS 896_ CARLA 901_ EMRQK 906_ EIPRV 911_ LEQLE 916_ DLDSR 921_ VLYYS 926_ ATKNG 931_ ILYRV 936_ GDGVY 941_ LPPEA 946_ FTFNI 951_ KLSSP 956_ VKRPR 961_ KEPVD 966_ EDLYP 971_ EHYRK 976_ YSDYI 981_ KGSNL 986_ DAPEP 991_ YRIGR 996_ IKEIF 1001_ CPKKS 1006_ NGRPN 1011_ ETDIK 1016_ IRVNK 1021_ FYRPE 1026_ NTHKS 1031_ TPASY 1036_ HADIN 1041_ LLYWS 1046_ DEEAV 1051_ VDFKA 1056_ VQGRC 1061_ TVEYG 1066_ EDLPE 1071_ CVQVY 1076_ SMGGP 1081_ NRFYF 1086_ LEAYN 1091_ AKSKS 1096_ FEDPP 1101_ NHARS 1106_ PGNKG 1111_ KGKGK 1116_ GKGKP 1121_ KSQAC 1126_ EPSEP 1131_ EIEIK 1136_ LPKLR 1141_ TLDVF 1146_ SGCGG 1151_ LSEGF 1156_ HQAGI 1161_ SDTLW 1166_ AIEMW 1171_ DPAAQ 1176_ AFRLN 1181_ NPGST 1186_ VFTED 1191_ CNILL 1196_ KLVMA 1201_ GETTN 1206_ SRGQR 1211_ LPQKG 1216_ DVEML 1221_ CGGPP 1226_ CQGFS 1231_ GMNRF 1236_ NSRTY 1241_ SKFKN 1246_ SLVVS 1251_ FLSYC 1256_ DYYRP 1261_ RFFLL 1266_ ENVRN 1271_ FVSFK 1276_ RSMVL 1281_ KLTLR 1286_ CLVRM 1291_ GYQCT 1296_ FGVLQ 1301_ AGQYG 1306_ VAQTR 1311_ RRAII 1316_ LAAAP 1321_ GEKLP 1326_ LFPEP 1331_ LHVFA 1336_ PRACQ 1341_ LSVVV 1346_ DDKKF 1351_ VSNIT 1356_ RLSSG 1361_ PFRTI 1366_ TVRDT 1371_ MSDLP 1376_ EVRNG 1381_ ASALE 1386_ ISYNG 1391_ EPQSW 1396_ FQRQL 1401_ RGAQY 1406_ QPILR 1411_ DHICK 1416_ DMSAL 1421_ VAARM 1426_ RHIPL 1431_ APGSD 1436_ WRDLP 1441_ NIEVR 1446_ LSDGT 1451_ MARKL 1456_ RYTHH 1461_ DRKNG 1466_ RSSSG 1471_ ALRGV 1476_ CSCVE 1481_ AGKAC 1486_ DPAAR 1491_ QFNTL 1496_ IPWCL 1501_ PHTGN 1506_ RHNHW 1511_ AGLYG 1516_ RLEWD 1521_ GFFST 1526_ TVTNP 1531_ EPMGK 1536_ QGRVL 1541_ HPEQH 1546_ RVVSV 1551_ RECAR 1556_ SQGFP 1561_ DTYRL 1566_ FGNIL 1571_ DKHRQ 1576_ VGNAV 1581_ PPPLA 1586_ KAIGL 1591_ EIKLC 1596_ MLAKA 1601_ RESAS 1606_ AKIKE 1611_EEAAK
1: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306)