Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin)
1_MQNSH 6_ SGVNQ 11_ LGGVF 16_ VNGRP 21_ LPDST 26_ RQKIV 31_ ELAHS 36_ GARPC 41_ DISRI 46_ LQVSN 51_ GCVSK 56_ ILGRY 61_ YETGS 66_ IRPRA 71_ IGGSK 76_ PRVAT 81_ PEVVS 86_ KIAQY 91_ KRECP 96_ SIFAW 101_ EIRDR 106_ LLSEG 111_ VCTND 116_ NIPSV 121_ SSINR 126_ VLRNL 131_ ASEKQ 136_ QMGAD 141_ GMYDK 146_ LRMLN 151_ GQTGS 156_ WGTRP 161_ GWYPG 166_ TSVPG 171_ QPTQD 176_ GCQQQ 181_ EGGGE 186_ NTNSI 191_ SSNGE 196_ DSDEA 201_ QMRLQ 206_ LKRKL 211_ QRNRT 216_ SFTQE 221_ QIEAL 226_ EKEFE 231_ RTHYP 236_ DVFAR 241_ ERLAA 246_ KIDLP 251_ EARIQ 256_ VWFSN 261_ RRAKW 266_ RREEK 271_ LRNQR 276_ RQASN 281_ TPSHI 286_ PISSS 291_ FSTSV 296_ YQPIP 301_ QPTTP 306_ VSSFT 311_ SGSML 316_ GRTDT 321_ ALTNT 326_ YSALP 331_ PMPSF 336_ TMANN 341_ LPMQP 346_ PVPSQ 351_ TSSYS 356_ CMLPT 361_ SPSVN 366_ GRSYD 371_ TYTPP 376_ HMQTH 381_ MNSQP 386_ MGTSG 391_ TTSTG 396_ LISPG 401_ VSVPV 406_ QVPGS 411_ EPDMS 416_QYWPR
1: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity)