Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
1_MSDFD 6_ EFERQ 11_ LNENK 16_ QERDK 21_ ENRHR 26_ KRSHS 31_ RSRSR 36_ DRKRR 41_ SRSRD 46_ RRNRD 51_ QRSAS 56_ RDRRR 61_ RSKPL 66_ TRGAK 71_ EEHGG 76_ LIRSP 81_ RHEKK 86_ KKVRK 91_ YWDVP 96_ PPGFE 101_ HITPM 106_ QYKAM 111_ QAAGQ 116_ IPATA 121_ LLPTM 126_ TPDGL 131_ AVTPT 136_ PVPVV 141_ GSQMT 146_ RQARR 151_ LYVGN 156_ IPFGI 161_ TEEAM 166_ MDFFN 171_ AQMRL 176_ GGLTQ 181_ APGNP 186_ VLAVQ 191_ INQDK 196_ NFAFL 201_ EFRSV 206_ DETTQ 211_ AMAFD 216_ GIIFQ 221_ GQSLK 226_ IRRPH 231_ DYQPL 236_ PGMSE 241_ NPSVY 246_ VPGVV 251_ STVVP 256_ DSAHK 261_ LFIGG 266_ LPNYL 271_ NDDQV 276_ KELLT 281_ SFGPL 286_ KAFNL 291_ VKDSA 296_ TGLSK 301_ GYAFC 306_ EYVDI 311_ NVTDQ 316_ AIAGL 321_ NGMQL 326_ GDKKL 331_ LVQRA 336_ SVGAK 341_ NATLV 346_ SPPST 351_ INQTP 356_ VTLQV 361_ PGLMS 366_ SQVQM 371_ GGHPT 376_ EVLCL 381_ MNMVL 386_ PEELL 391_ DDEEY 396_ EEIVE 401_ DVRDE 406_ CSKYG 411_ LVKSI 416_ EIPRP 421_ VDGVE 426_ VPGCG 431_ KIFVE 436_ FTSVF 441_ DCQKA 446_ MQGLT 451_ GRKFA 456_ NRVVV 461_ TKYCD 466_PDSYH
1: Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186)