ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD)
1_MEWNG 6_ LKMII 11_ STMEP 16_ QVSNG 21_ PTSNT 26_ SNGPS 31_ SNNRN 36_ CPSPM 41_ QTGAT 46_ TDDSK 51_ TNLIV 56_ NYLPQ 61_ NMTQE 66_ EFRSL 71_ FGSIG 76_ EIESC 81_ KLVRD 86_ KITGQ 91_ SLGYG 96_ FVNYI 101_ DPKDA 106_ EKAIN 111_ TLNGL 116_ RLQTK 121_ TIKVS 126_ YARPS 131_ SASIR 136_ DANLY 141_ VSGLP 146_ KTMTQ 151_ KELEQ 156_ LFSQY 161_ GRIIT 166_ SRILV 171_ DQVTG 176_ VSRGV 181_ GFIRF 186_ DKRIE 191_ AEEAI 196_ KGLNG 201_ QKPSG 206_ ATEPI 211_ TVKFA 216_ NNPSQ 221_ KSSQA 226_ LLSQL 231_ YQSPN 236_ RRYPG 241_ PLHHQ 246_ AQRFR 251_ LDNLL 256_ NMAYG 261_ VKRLM 266_ SGPVP 271_ PSACP 276_ PRFSP 281_ ITIDG 286_ MTSLV 291_ GMNIP 296_ GHTGT 301_ GWCIF 306_ VYNLS 311_ PDSDE 316_ SVLWQ 321_ LFGPF 326_ GAVNN 331_ VKVIR 336_ DFNTN 341_ KCKGF 346_ GFVTM 351_ TNYDE 356_ AAMAI 361_ ASLNG 366_ YRLGD 371_ RVLQV 376_SFKTN
1: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:7898713). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636)