3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]
1_MGWSC 6_ LVTGA 11_ GGLLG 16_ QRIVR 21_ LLVEE 26_ KELKE 31_ IRALD 36_ KAFRP 41_ ELREE 46_ FSKLQ 51_ NRTKL 56_ TVLEG 61_ DILDE 66_ PFLKR 71_ ACQDV 76_ SVVIH 81_ TACII 86_ DVFGV 91_ THRES 96_ IMNVN 101_ VKGTQ 106_ LLLEA 111_ CVQAS 116_ VPVFI 121_ YTSSI 126_ EVAGP 131_ NSYKE 136_ IIQNG 141_ HEEEP 146_ LENTW 151_ PTPYP 156_ YSKKL 161_ AEKAV 166_ LAANG 171_ WNLKN 176_ GDTLY 181_ TCALR 186_ PTYIY 191_ GEGGP 196_ FLSAS 201_ INEAL 206_ NNNGI 211_ LSSVG 216_ KFSTV 221_ NPVYV 226_ GNVAW 231_ AHILA 236_ LRALR 241_ DPKKA 246_ PSVRG 251_ QFYYI 256_ SDDTP 261_ HQSYD 266_ NLNYI 271_ LSKEF 276_ GLRLD 281_ SRWSL 286_ PLTLM 291_ YWIGF 296_ LLEVV 301_ SFLLS 306_ PIYSY 311_ QPPFN 316_ RHTVT 321_ LSNSV 326_ FTFSY 331_ KKAQR 336_ DLAYK 341_ PLYSW 346_ EEAKQ 351_ KTVEW 356_ VGSLV 361_ DRHKE 366_TLKSK
1: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids