High mobility group protein B2 (High mobility group protein 2) (HMG-2)
1_MGKGD 6_ PNKPR 11_ GKMSS 16_ YAFFV 21_ QTCRE 26_ EHKKK 31_ HPDSS 36_ VNFAE 41_ FSKKC 46_ SERWK 51_ TMSAK 56_ EKSKF 61_ EDMAK 66_ SDKAR 71_ YDREM 76_ KNYVP 81_ PKGDK 86_ KGKKK 91_ DPNAP 96_ KRPPS 101_ AFFLF 106_ CSEHR 111_ PKIKS 116_ EHPGL 121_ SIGDT 126_ AKKLG 131_ EMWSE 136_ QSAKD 141_ KQPYE 146_ QKAAK 151_ LKEKY 156_ EKDIA 161_ AYRAK 166_ GKSEA 171_ GKKGP 176_ GRPTG 181_ SKKKN 186_ EPEDE 191_ EEEEE 196_ EEDED 201_EEEED
1: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity)