NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)
1_MNKQR 6_ GTFSE 11_ VSLAQ 16_ DPKRQ 21_ QRKPK 26_ GNKSS 31_ ISGTE 36_ QEIFQ 41_ VELNL 46_ QNPSL 51_ NHQGI 56_ DKIYD 61_ CQGLL 66_ PPPEK 71_ LTAEV 76_ LGIIC 81_ IVLMA 86_ TVLKT 91_ IVLIP 96_ FLEQN 101_ NFSPN 106_ TRTQK 111_ ARHCG 116_ HCPEE 121_ WITYS 126_ NSCYY 131_ IGKER 136_ RTWEE 141_ SLLAC 146_ TSKNS 151_ SLLSI 156_ DNEEE 161_ MKFLA 166_ SILPS 171_ SWIGV 176_ FRNSS 181_ HHPWV 186_ TINGL 191_ AFKHK 196_ IKDSD 201_ NAELN 206_ CAVLQ 211_ VNRLK 216_ SAQCG 221_ SSMIY 226_HCKHK
1: Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:30134159, PubMed:37264229, PubMed:9754572). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:20952657, PubMed:21825173). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:15940674, PubMed:9655483)