NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
1_MGWIR 6_ GRRSR 11_ HSWEM 16_ SEFHN 21_ YNLDL 26_ KKSDF 31_ STRWQ 36_ KQRCP 41_ VVKSK 46_ CRENA 51_ SPFFF 56_ CCFIA 61_ VAMGI 66_ RFIIM 71_ VTIWS 76_ AVFLN 81_ SLFNQ 86_ EVQIP 91_ LTESY 96_ CGPCP 101_ KNWIC 106_ YKNNC 111_ YQFFD 116_ ESKNW 121_ YESQA 126_ SCMSQ 131_ NASLL 136_ KVYSK 141_ EDQDL 146_ LKLVK 151_ SYHWM 156_ GLVHI 161_ PTNGS 166_ WQWED 171_ GSILS 176_ PNLLT 181_ IIEMQ 186_ KGDCA 191_ LYASS 196_ FKGYI 201_ ENCST 206_ PNTYI 211_CMQRT
1: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4