Adenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)
1_MASKL 6_ LRAVI 11_ LGPPG 16_ SGKGT 21_ VCQRI 26_ AQNFG 31_ LQHLS 36_ SGHFL 41_ RENIK 46_ ASTEV 51_ GEMAK 56_ QYIEK 61_ SLLVP 66_ DHVIT 71_ RLMMS 76_ ELENR 81_ RGQHW 86_ LLDGF 91_ PRTLG 96_ QAEAL 101_ DKICE 106_ VDLVI 111_ SLNIP 116_ FETLK 121_ DRLSR 126_ RWIHP 131_ PSGRV 136_ YNLDF 141_ NPPHV 146_ HGIDD 151_ VTGEP 156_ LVQQE 161_ DDKPE 166_ AVAAR 171_ LRQYK 176_ DVAKP 181_ VIELY 186_ KSRGV 191_ LHQFS 196_ GTETN 201_ KIWPY 206_ VYTLF 211_ SNKIT 216_PIQSK
1: Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP (PubMed:19766732). Phosphorylates only AMP when using GTP as phosphate donor (PubMed:19766732). In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor (PubMed:19766732, PubMed:23416111). Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors (PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435)