Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)
1_MGNRH 6_ AKASS 11_ PQGFD 16_ VDRDA 21_ KKLNK 26_ ACKGM 31_ GTNEA 36_ AIIEI 41_ LSGRT 46_ SDERQ 51_ QIKQK 56_ YKATY 61_ GKELE 66_ EVLKS 71_ ELSGN 76_ FEKTA 81_ LALLD 86_ RPSEY 91_ AARQL 96_ QKAMK 101_ GLGTD 106_ ESVLI 111_ EVLCT 116_ RTNKE 121_ IIAIK 126_ EAYQR 131_ LFDRS 136_ LESDV 141_ KGDTS 146_ GNLKK 151_ ILVSL 156_ LQANR 161_ NEGDD 166_ VDKDL 171_ AGQDA 176_ KDLYD 181_ AGEGR 186_ WGTDE 191_ LAFNE 196_ VLAKR 201_ SYKQL 206_ RATFQ 211_ AYQIL 216_ IGKDI 221_ EEAIE 226_ EETSG 231_ DLQKA 236_ YLTLV 241_ RCAQD 246_ CEDYF 251_ AERLY 256_ KSMKG 261_ AGTDE 266_ ETLIR 271_ IVVTR 276_ AEVDL 281_ QGIKA 286_ KFQEK 291_ YQKSL 296_ SDMVR 301_ SDTSG 306_ DFRKL 311_LVALL
1: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605)
2: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium