Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]
1_MKTPW 6_ KVLLG 11_ LLGAA 16_ ALVTI 21_ ITVPV 26_ VLLNK 31_ GTDDA 36_ TADSR 41_ KTYTL 46_ TDYLK 51_ NTYRL 56_ KLYSL 61_ RWISD 66_ HEYLY 71_ KQENN 76_ ILVFN 81_ AEYGN 86_ SSVFL 91_ ENSTF 96_ DEFGH 101_ SINDY 106_ SISPD 111_ GQFIL 116_ LEYNY 121_ VKQWR 126_ HSYTA 131_ SYDIY 136_ DLNKR 141_ QLITE 146_ ERIPN 151_ NTQWV 156_ TWSPV 161_ GHKLA 166_ YVWNN 171_ DIYVK 176_ IEPNL 181_ PSYRI 186_ TWTGK 191_ EDIIY 196_ NGITD 201_ WVYEE 206_ EVFSA 211_ YSALW 216_ WSPNG 221_ TFLAY 226_ AQFND 231_ TEVPL 236_ IEYSF 241_ YSDES 246_ LQYPK 251_ TVRVP 256_ YPKAG 261_ AVNPT 266_ VKFFV 271_ VNTDS 276_ LSSVT 281_ NATSI 286_ QITAP 291_ ASMLI 296_ GDHYL 301_ CDVTW 306_ ATQER 311_ ISLQW 316_ LRRIQ 321_ NYSVM 326_ DICDY 331_ DESSG 336_ RWNCL 341_ VARQH 346_ IEMST 351_ TGWVG 356_ RFRPS 361_ EPHFT 366_ LDGNS 371_ FYKII 376_ SNEEG 381_ YRHIC 386_ YFQID 391_ KKDCT 396_ FITKG 401_ TWEVI 406_ GIEAL 411_ TSDYL 416_ YYISN 421_ EYKGM 426_ PGGRN 431_ LYKIQ 436_ LSDYT 441_ KVTCL 446_ SCELN 451_ PERCQ 456_ YYSVS 461_ FSKEA 466_ KYYQL 471_ RCSGP 476_ GLPLY 481_ TLHSS 486_ VNDKG 491_ LRVLE 496_ DNSAL 501_ DKMLQ 506_ NVQMP 511_ SKKLD 516_ FIILN 521_ ETKFW 526_ YQMIL 531_ PPHFD 536_ KSKKY 541_ PLLLD 546_ VYAGP 551_ CSQKA 556_ DTVFR 561_ LNWAT 566_ YLAST 571_ ENIIV 576_ ASFDG 581_ RGSGY 586_ QGDKI 591_ MHAIN 596_ RRLGT 601_ FEVED 606_ QIEAA 611_ RQFSK 616_ MGFVD 621_ NKRIA 626_ IWGWS 631_ YGGYV 636_ TSMVL 641_ GSGSG 646_ VFKCG 651_ IAVAP 656_ VSRWE 661_ YYDSV 666_ YTERY 671_ MGLPT 676_ PEDNL 681_ DHYRN 686_ STVMS 691_ RAENF 696_ KQVEY 701_ LLIHG 706_ TADDN 711_ VHFQQ 716_ SAQIS 721_ KALVD 726_ VGVDF 731_ QAMWY 736_ TDEDH 741_ GIASS 746_ TAHQH 751_ IYTHM 756_ SHFIK 761_QCFSL
1: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:10593948, PubMed:16651416). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:10570924, PubMed:16254193). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948)
2: (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2