Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]
1_MAVLP 6_ GPLQL 11_ LGVLL 16_ TISLS 21_ SIRLI 26_ QAGAY 31_ YGIKP 36_ LPPQI 41_ PPQMP 46_ PQIPQ 51_ YQPLG 56_ QQVPH 61_ MPLAK 66_ DGLAM 71_ GKEMP 76_ HLQYG 81_ KEYPH 86_ LPQYM 91_ KEIQP 96_ APRMG 101_ KEAVP 106_ KKGKE 111_ IPLAS 116_ LRGEQ 121_ GPRGE 126_ PGPRG 131_ PPGPP 136_ GLPGH 141_ GIPGI 146_ KGKPG 151_ PQGYP 156_ GVGKP 161_ GMPGM 166_ PGKPG 171_ AMGMP 176_ GAKGE 181_ IGQKG 186_ EIGPM 191_ GIPGP 196_ QGPPG 201_ PHGLP 206_ GIGKP 211_ GGPGL 216_ PGQPG 221_ PKGDR 226_ GPKGL 231_ PGPQG 236_ LRGPK 241_ GDKGF 246_ GMPGA 251_ PGVKG 256_ PPGMH 261_ GPPGP 266_ VGLPG 271_ VGKPG 276_ VTGFP 281_ GPQGP 286_ LGKPG 291_ APGEP 296_ GPQGP 301_ IGVPG 306_ VQGPP 311_ GIPGI 316_ GKPGQ 321_ DGIPG 326_ QPGFP 331_ GGKGE 336_ QGLPG 341_ LPGPP 346_ GLPGI 351_ GKPGF 356_ PGPKG 361_ DRGMG 366_ GVPGA 371_ LGPRG 376_ EKGPI 381_ GAPGI 386_ GGPPG 391_ EPGLP 396_ GIPGP 401_ MGPPG 406_ AIGFP 411_ GPKGE 416_ GGIVG 421_ PQGPP 426_ GPKGE 431_ PGLQG 436_ FPGKP 441_ GFLGE 446_ VGPPG 451_ MRGLP 456_ GPIGP 461_ KGEAG 466_ QKGVP 471_ GLPGV 476_ PGLLG 481_ PKGEP 486_ GIPGD 491_ QGLQG 496_ PPGIP 501_ GIGGP 506_ SGPIG 511_ PPGIP 516_ GPKGE 521_ PGLPG 526_ PPGFP 531_ GIGKP 536_ GVAGL 541_ HGPPG 546_ KPGAL 551_ GPQGQ 556_ PGLPG 561_ PPGPP 566_ GPPGP 571_ PAVMP 576_ PTPPP 581_ QGEYL 586_ PDMGL 591_ GIDGV 596_ KPPHA 601_ YGAKK 606_ GKNGG 611_ PAYEM 616_ PAFTA 621_ ELTAP 626_ FPPVG 631_ APVKF 636_ NKLLY 641_ NGRQN 646_ YNPQT 651_ GIFTC 656_ EVPGV 661_ YYFAY 666_ HVHCK 671_ GGNVW 676_ VALFK 681_ NNEPV 686_ MYTYD 691_ EYKKG 696_ FLDQA 701_ SGSAV 706_ LLLRP 711_ GDRVF 716_ LQMPS 721_ EQAAG 726_ LYAGQ 731_ YVHSS 736_FSGYL
1: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis
2: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis