CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
1_MAALV 6_ LEDGS 11_ VLRGQ 16_ PFGAA 21_ VSTAG 26_ EVVFQ 31_ TGMVG 36_ YPEAL 41_ TDPSY 46_ KAQIL 51_ VLTYP 56_ LIGNY 61_ GIPPD 66_ EMDEF 71_ GLCKW 76_ FESSG 81_ IHVAA 86_ LVVGE 91_ CCPTP 96_ SHWSA 101_ TRTLH 106_ EWLQQ 111_ HGIPG 116_ LQGVD 121_ TRELT 126_ KKLRE 131_ QGSLL 136_ GKLVQ 141_ NGTEP 146_ SSLPF 151_ LDPNA 156_ RPLVP 161_ EVSIK 166_ TPRVF 171_ NTGGA 176_ PRILA 181_ LDCGL 186_ KYNQI 191_ RCLCQ 196_ RGAEV 201_ TVVPW 206_ DHALD 211_ SQEYE 216_ GLFLS 221_ NGPGD 226_ PASYP 231_ SVVST 236_ LSRVL 241_ SEPNP 246_ RPVFG 251_ ICLGH 256_ QLLAL 261_ AIGAK 266_ TYKMR 271_ YGNRG 276_ HNQPC 281_ LLVGS 286_ GRCFL 291_ TSQNH 296_ GFAVE 301_ TDSLP 306_ ADWAP 311_ LFTNA 316_ NDGSN 321_ EGIVH 326_ NSLPF 331_ FSVQF 336_ HPEHQ 341_ AGPSD 346_ MELLF 351_ DIFLE 356_ TVKEA 361_ TAGNP 366_ GGQTV 371_ RERLT 376_ ERLCP 381_ PGIPT 386_ PGSGL 391_ PPPRK 396_ VLILG 401_ SGGLS 406_ IGQAG 411_ EFDYS 416_ GSQAI 421_ KALKE 426_ ENIQT 431_ LLINP 436_ NIATV 441_ QTSQG 446_ LADKV 451_ YFLPI 456_ TPHYV 461_ TQVIR 466_ NERPD 471_ GVLLT 476_ FGGQT 481_ ALNCG 486_ VELTK 491_ AGVLA 496_ RYGVR 501_ VLGTP 506_ VETIE 511_ LTEDR 516_ RAFAA 521_ RMAEI 526_ GEHVA 531_ PSEAA 536_ NSLEQ 541_ AQAAA 546_ ERLGY 551_ PVLVR 556_ AAFAL 561_ GGLGS 566_ GFASN 571_ REELS 576_ ALVAP 581_ AFAHT 586_ SQVLV 591_ DKSLK 596_ GWKEI 601_ EYEVV 606_ RDAYG 611_ NCVTV 616_ CNMEN 621_ LDPLG 626_ IHTGE 631_ SIVVA 636_ PSQTL 641_ NDREY 646_ QLLRQ 651_ TAIKV 656_ TQHLG 661_ IVGEC 666_ NVQYA 671_ LNPES 676_ EQYYI 681_ IEVNA 686_ RLSRS 691_ SALAS 696_ KATGY 701_ PLAYV 706_ AAKLA 711_ LGIPL 716_ PELRN 721_ SVTGG 726_ TAAFE 731_ PSVDY 736_ CVVKI 741_ PRWDL 746_ SKFLR 751_ VSTKI 756_ GSCMK 761_ SVGEV 766_ MGIGR 771_ SFEEA 776_ FQKAL 781_ RMVDE 786_ NCVGF 791_ DHTVK 796_ PVSDM 801_ ELETP 806_ TDKRI 811_ FVVAA 816_ ALWAG 821_ YSVDR 826_ LYELT 831_ RIDRW 836_ FLHRM 841_ KRIIA 846_ HAQLL 851_ EQHRG 856_ QPLPP 861_ DLLQQ 866_ AKCLG 871_ FSDKQ 876_ IALAV 881_ LSTEL 886_ AVRKL 891_ RQELG 896_ ICPAV 901_ KQIDT 906_ VAAEW 911_ PAQTN 916_ YLYLT 921_ YWGTT 926_ HDLTF 931_ RTPHV 936_ LVLGS 941_ GVYRI 946_ GSSVE 951_ FDWCA 956_ VGCIQ 961_ QLRKM 966_ GYKTI 971_ MVNYN 976_ PETVS 981_ TDYDM 986_ CDRLY 991_ FDEIS 996_ FEVVM 1001_ DIYEL 1006_ ENPEG 1011_ VILSM 1016_ GGQLP 1021_ NNMAM 1026_ ALHRQ 1031_ QCRVL 1036_ GTSPE 1041_ AIDSA 1046_ ENRFK 1051_ FSRLL 1056_ DTIGI 1061_ SQPQW 1066_ RELSD 1071_ LESAR 1076_ QFCQT 1081_ VGYPC 1086_ VVRPS 1091_ YVLSG 1096_ AAMNV 1101_ AYTDG 1106_ DLERF 1111_ LSSAA 1116_ AVSKE 1121_ HPVVI 1126_ SKFIQ 1131_ EAKEI 1136_ DVDAV 1141_ ASDGV 1146_ VAAIA 1151_ ISEHV 1156_ ENAGV 1161_ HSGDA 1166_ TLVTP 1171_ PQDIT 1176_ AKTLE 1181_ RIKAI 1186_ VHAVG 1191_ QELQV 1196_ TGPFN 1201_ LQLIA 1206_ KDDQL 1211_ KVIEC 1216_ NVRVS 1221_ RSFPF 1226_ VSKTL 1231_ GVDLV 1236_ ALATR 1241_ VIMGE 1246_ EVEPV 1251_ GLMTG 1256_ SGVVG 1261_ VKVPQ 1266_ FSFSR 1271_ LAGAD 1276_ VVLGV 1281_ EMTST 1286_ GEVAG 1291_ FGESR 1296_ CEAYL 1301_ KAMLS 1306_ TGFKI 1311_ PKKNI 1316_ LLTIG 1321_ SYKNK 1326_ SELLP 1331_ TVRLL 1336_ ESLGY 1341_ SLYAS 1346_ LGTAD 1351_ FYTEH 1356_ GVKVT 1361_ AVDWH 1366_ FEEAV 1371_ DGECP 1376_ PQRSI 1381_ LEQLA 1386_ EKNFE 1391_ LVINL 1396_ SMRGA 1401_ GGRRL 1406_ SSFVT 1411_ KGYRT 1416_ RRLAA 1421_ DFSVP 1426_ LIIDI 1431_ KCTKL 1436_ FVEAL 1441_ GQIGP 1446_ APPLK 1451_ VHVDC 1456_ MTSQK 1461_ LVRLP 1466_ GLIDV 1471_ HVHLR 1476_ EPGGT 1481_ HKEDF 1486_ ASGTA 1491_ AALAG 1496_ GITMV 1501_ CAMPN 1506_ TRPPI 1511_ IDAPA 1516_ LALAQ 1521_ KLAEA 1526_ GARCD 1531_ FALFL 1536_ GASSE 1541_ NAGTL 1546_ GTVAG 1551_ SAAGL 1556_ KLYLN 1561_ ETFSE 1566_ LRLDS 1571_ VVQWM 1576_ EHFET 1581_ WPSHL 1586_ PIVAH 1591_ AEQQT 1596_ VAAVL 1601_ MVAQL 1606_ TQRSV 1611_ HICHV 1616_ ARKEE 1621_ ILLIK 1626_ AAKAR 1631_ GLPVT 1636_ CEVAP 1641_ HHLFL 1646_ SHDDL 1651_ ERLGP 1656_ GKGEV 1661_ RPELG 1666_ SRQDV 1671_ EALWE 1676_ NMAVI 1681_ DCFAS 1686_ DHAPH 1691_ TLEEK 1696_ CGSRP 1701_ PPGFP 1706_ GLETM 1711_ LPLLL 1716_ TAVSE 1721_ GRLSL 1726_ DDLLQ 1731_ RLHHN 1736_ PRRIF 1741_ HLPPQ 1746_ EDTYV 1751_ EVDLE 1756_ HEWTI 1761_ PSHMP 1766_ FSKAH 1771_ WTPFE 1776_ GQKVK 1781_ GTVRR 1786_ VVLRG 1791_ EVAYI 1796_ DGQVL 1801_ VPPGY 1806_ GQDVR 1811_ KWPQG 1816_ AVPQL 1821_ PPSAP 1826_ ATSEM 1831_ TTTPE 1836_ RPRRG 1841_ IPGLP 1846_ DGRFH 1851_ LPPRI 1856_ HRASD 1861_ PGLPA 1866_ EEPKE 1871_ KSSRK 1876_ VAEPE 1881_ LMGTP 1886_ DGTCY 1891_ PPPPV 1896_ PRQAS 1901_ PQNLG 1906_ TPGLL 1911_ HPQTS 1916_ PLLHS 1921_ LVGQH 1926_ ILSVQ 1931_ QFTKD 1936_ QMSHL 1941_ FNVAH 1946_ TLRMM 1951_ VQKER 1956_ SLDIL 1961_ KGKVM 1966_ ASMFY 1971_ EVSTR 1976_ TSSSF 1981_ AAAMA 1986_ RLGGA 1991_ VLSFS 1996_ EATSS 2001_ VQKGE 2006_ SLADS 2011_ VQTMS 2016_ CYADV 2021_ VVLRH 2026_ PQPGA 2031_ VELAA 2036_ KHCRR 2041_ PVINA 2046_ GDGVG 2051_ EHPTQ 2056_ ALLDI 2061_ FTIRE 2066_ ELGTV 2071_ NGMTI 2076_ TMVGD 2081_ LKHGR 2086_ TVHSL 2091_ ACLLT 2096_ QYRVS 2101_ LRYVA 2106_ PPSLR 2111_ MPPTV 2116_ RAFVA 2121_ SRGTK 2126_ QEEFE 2131_ SIEEA 2136_ LPDTD 2141_ VLYMT 2146_ RIQKE 2151_ RFGST 2156_ QEYEA 2161_ CFGQF 2166_ ILTPH 2171_ IMTRA 2176_ KKKMV 2181_ VMHPM 2186_ PRVNE 2191_ ISVEV 2196_ DSDPR 2201_ AAYFR 2206_ QAENG 2211_ MYIRM 2216_ALLAT
1: Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate