Gene name: PDE4A

Uniprot entry:

P27815

Protein names:

cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46)

Protein sequence:

1_MEPPT 6_ VPSER 11_ SLSLS 16_ LPGPR 21_ EGQAT 26_ LKPPP 31_ QHLWR 36_ QPRTP 41_ IRIQQ 46_ RGYSD 51_ SAERA 56_ ERERQ 61_ PHRPI 66_ ERADA 71_ MDTSD 76_ RPGLR 81_ TTRMS 86_ WPSSF 91_ HGTGT 96_ GSGGA 101_ GGGSS 106_ RRFEA 111_ ENGPT 116_ PSPGR 121_ SPLDS 126_ QASPG 131_ LVLHA 136_ GAATS 141_ QRRES 146_ FLYRS 151_ DSDYD 156_ MSPKT 161_ MSRNS 166_ SVTSE 171_ AHAED 176_ LIVTP 181_ FAQVL 186_ ASLRS 191_ VRSNF 196_ SLLTN 201_ VPVPS 206_ NKRSP 211_ LGGPT 216_ PVCKA 221_ TLSEE 226_ TCQQL 231_ ARETL 236_ EELDW 241_ CLEQL 246_ ETMQT 251_ YRSVS 256_ EMASH 261_ KFKRM 266_ LNREL 271_ THLSE 276_ MSRSG 281_ NQVSE 286_ YISTT 291_ FLDKQ 296_ NEVEI 301_ PSPTM 306_ KEREK 311_ QQAPR 316_ PRPSQ 321_ PPPPP 326_ VPHLQ 331_ PMSQI 336_ TGLKK 341_ LMHSN 346_ SLNNS 351_ NIPRF 356_ GVKTD 361_ QEELL 366_ AQELE 371_ NLNKW 376_ GLNIF 381_ CVSDY 386_ AGGRS 391_ LTCIM 396_ YMIFQ 401_ ERDLL 406_ KKFRI 411_ PVDTM 416_ VTYML 421_ TLEDH 426_ YHADV 431_ AYHNS 436_ LHAAD 441_ VLQST 446_ HVLLA 451_ TPALD 456_ AVFTD 461_ LEILA 466_ ALFAA 471_ AIHDV 476_ DHPGV 481_ SNQFL 486_ INTNS 491_ ELALM 496_ YNDES 501_ VLENH 506_ HLAVG 511_ FKLLQ 516_ EDNCD 521_ IFQNL 526_ SKRQR 531_ QSLRK 536_ MVIDM 541_ VLATD 546_ MSKHM 551_ TLLAD 556_ LKTMV 561_ ETKKV 566_ TSSGV 571_ LLLDN 576_ YSDRI 581_ QVLRN 586_ MVHCA 591_ DLSNP 596_ TKPLE 601_ LYRQW 606_ TDRIM 611_ AEFFQ 616_ QGDRE 621_ RERGM 626_ EISPM 631_ CDKHT 636_ ASVEK 641_ SQVGF 646_ IDYIV 651_ HPLWE 656_ TWADL 661_ VHPDA 666_ QEILD 671_ TLEDN 676_ RDWYY 681_ SAIRQ 686_ SPSPP 691_ PEEES 696_ RGPGH 701_ PPLPD 706_ KFQFE 711_ LTLEE 716_ EEEEE 721_ ISMAQ 726_ IPCTA 731_ QEALT 736_ AQGLS 741_ GVEEA 746_ LDATI 751_ AWEAS 756_ PAQES 761_ LEVMA 766_ QEASL 771_ EAELE 776_ AVYLT 781_ QQAQS 786_ TGSAP 791_ VAPDE 796_ FSSRE 801_ EFVVA 806_ VSHSS 811_ PSALA 816_ LQSPL 821_ LPAWR 826_ TLSVS 831_ EHAPG 836_ LPGLP 841_ STAAE 846_ VEAQR 851_ EHQAA 856_ KRACS 861_ ACAGT 866_ FGEDT 871_ SALPA 876_ PGGGG 881_SGGDP

Protein annotations

Protein functions:

1: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes

2: Efficiently hydrolyzes cAMP

3: Efficiently hydrolyzes cAMP

4: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP

5: Efficiently hydrolyzes cAMP

6: Efficiently hydrolyzes cAMP

7: Efficiently hydrolyzes cAMP