Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]
1_MLRLY 6_ VLVMG 11_ VSAFT 16_ LQPAA 21_ HTGAA 26_ RSCRF 31_ RGRHY 36_ KREFR 41_ LEGEP 46_ VALRC 51_ PQVPY 56_ WLWAS 61_ VSPRI 66_ NLTWH 71_ KNDSA 76_ RTVPG 81_ EEETR 86_ MWAQD 91_ GALWL 96_ LPALQ 101_ EDSGT 106_ YVCTT 111_ RNASY 116_ CDKMS 121_ IELRV 126_ FENTD 131_ AFLPF 136_ ISYPQ 141_ ILTLS 146_ TSGVL 151_ VCPDL 156_ SEFTR 161_ DKTDV 166_ KIQWY 171_ KDSLL 176_ LDKDN 181_ EKFLS 186_ VRGTT 191_ HLLVH 196_ DVALE 201_ DAGYY 206_ RCVLT 211_ FAHEG 216_ QQYNI 221_ TRSIE 226_ LRIKK 231_ KKEET 236_ IPVII 241_ SPLKT 246_ ISASL 251_ GSRLT 256_ IPCKV 261_ FLGTG 266_ TPLTT 271_ MLWWT 276_ ANDTH 281_ IESAY 286_ PGGRV 291_ TEGPR 296_ QEYSE 301_ NNENY 306_ IEVPL 311_ IFDPV 316_ TREDL 321_ HMDFK 326_ CVVHN 331_ TLSFQ 336_ TLRTT 341_ VKEAS 346_ STFSW 351_ GIVLA 356_ PLSLA 361_ FLVLG 366_ GIWMH 371_ RRCKH 376_ RTGKA 381_ DGLTV 386_ LWPHH 391_QDFQS
1: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors