Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
1_MSAEG 6_ YQYRA 11_ LYDYK 16_ KEREE 21_ DIDLH 26_ LGDIL 31_ TVNKG 36_ SLVAL 41_ GFSDG 46_ QEARP 51_ EEIGW 56_ LNGYN 61_ ETTGE 66_ RGDFP 71_ GTYVE 76_ YIGRK 81_ KISPP 86_ TPKPR 91_ PPRPL 96_ PVAPG 101_ SSKTE 106_ ADVEQ 111_ QALTL 116_ PDLAE 121_ QFAPP 126_ DIAPP 131_ LLIKL 136_ VEAIE 141_ KKGLE 146_ CSTLY 151_ RTQSS 156_ SNLAE 161_ LRQLL 166_ DCDTP 171_ SVDLE 176_ MIDVH 181_ VLADA 186_ FKRYL 191_ LDLPN 196_ PVIPA 201_ AVYSE 206_ MISLA 211_ PEVQS 216_ SEEYI 221_ QLLKK 226_ LIRSP 231_ SIPHQ 236_ YWLTL 241_ QYLLK 246_ HFFKL 251_ SQTSS 256_ KNLLN 261_ ARVLS 266_ EIFSP 271_ MLFRF 276_ SAASS 281_ DNTEN 286_ LIKVI 291_ EILIS 296_ TEWNE 301_ RQPAP 306_ ALPPK 311_ PPKPT 316_ TVANN 321_ GMNNN 326_ MSLQD 331_ AEWYW 336_ GDISR 341_ EEVNE 346_ KLRDT 351_ ADGTF 356_ LVRDA 361_ STKMH 366_ GDYTL 371_ TLRKG 376_ GNNKL 381_ IKIFH 386_ RDGKY 391_ GFSDP 396_ LTFSS 401_ VVELI 406_ NHYRN 411_ ESLAQ 416_ YNPKL 421_ DVKLL 426_ YPVSK 431_ YQQDQ 436_ VVKED 441_ NIEAV 446_ GKKLH 451_ EYNTQ 456_ FQEKS 461_ REYDR 466_ LYEEY 471_ TRTSQ 476_ EIQMK 481_ RTAIE 486_ AFNET 491_ IKIFE 496_ EQCQT 501_ QERYS 506_ KEYIE 511_ KFKRE 516_ GNEKE 521_ IQRIM 526_ HNYDK 531_ LKSRI 536_ SEIID 541_ SRRRL 546_ EEDLK 551_ KQAAE 556_ YREID 561_ KRMNS 566_ IKPDL 571_ IQLRK 576_ TRDQY 581_ LMWLT 586_ QKGVR 591_ QKKLN 596_ EWLGN 601_ ENTED 606_ QYSLV 611_ EDDED 616_ LPHHD 621_ EKTWN 626_ VGSSN 631_ RNKAE 636_ NLLRG 641_ KRDGT 646_ FLVRE 651_ SSKQG 656_ CYACS 661_ VVVDG 666_ EVKHC 671_ VINKT 676_ ATGYG 681_ FAEPY 686_ NLYSS 691_ LKELV 696_ LHYQH 701_ TSLVQ 706_ HNDSL 711_ NVTLA 716_YPVYA
1: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923)