Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit]
1_MQSPW 6_ KILTV 11_ APLFL 16_ LLSLQ 21_ SSASP 26_ ANDDQ 31_ SRPSL 36_ SNGHT 41_ CVGCV 46_ LVVSV 51_ IEQLA 56_ QVHNS 61_ TVQAS 66_ MERLC 71_ SYLPE 76_ KLFLK 81_ TTCYL 86_ VIDKF 91_ GSDII 96_ KLLSA 101_ DMNAD 106_ VVCHT 111_ LEFCK 116_ QNTGQ 121_ PLCHL 126_ YPLPK 131_ ETWKF 136_ TLQKA 141_ RQIVK 146_ KSPIL 151_ KYSRS 156_ GSDIC 161_ SLPVL 166_ AKICQ 171_ KIKLA 176_ MEQSV 181_ PFKDV 186_ DSDKY 191_ SVFPT 196_ LRGYH 201_ WRGRD 206_ CNDSD 211_ ESVYP 216_ GRRPN 221_ NWDVH 226_ QDSNC 231_ NGIWG 236_ VDPKD 241_ GVPYE 246_ KKFCE 251_ GSQPR 256_ GIILL 261_ GDSAG 266_ AHFHI 271_ SPEWI 276_ TASQM 281_ SLNSF 286_ INLPT 291_ ALTNE 296_ LDWPQ 301_ LSGAT 306_ GFLDS 311_ TVGIK 316_ EKSIY 321_ LRLWK 326_ RNHCN 331_ HRDYQ 336_ NISRN 341_ GASSR 346_ NLKKF 351_ IESLS 356_ RNKVL 361_ DYPAI 366_ VIYAM 371_ IGNDV 376_ CSGKS 381_ DPVPA 386_ MTTPE 391_ KLYSN 396_ VMQTL 401_ KHLNS 406_ HLPNG 411_ SHVIL 416_ YGLPD 421_ GTFLW 426_ DNLHN 431_ RYHPL 436_ GQLNK 441_ DMTYA 446_ QLYSF 451_ LNCLQ 456_ VSPCH 461_ GWMSS 466_ NKTLR 471_ TLTSE 476_ RAEQL 481_ SNTLK 486_ KIAAS 491_ EKFTN 496_ FNLFY 501_ MDFAF 506_ HEIIQ 511_ EWQKR 516_ GGQPW 521_ QLIEP 526_ VDGFH 531_ PNEVA 536_ LLLLA 541_ DHFWK 546_ KVQLQ 551_ WPQIL 556_ GKENP 561_ FNPQI 566_KQVFG
1: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:29343645, PubMed:8089145). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity)