Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)
1_MALLD 6_ VCGAP 11_ RGQRP 16_ ESALP 21_ VAGSG 26_ RRSDP 31_ GHYSF 36_ SMRSP 41_ ELALP 46_ RGMQP 51_ TEFFQ 56_ SLGGD 61_ GERNV 66_ QIEMA 71_ HGTTT 76_ LAFKF 81_ QHGVI 86_ AAVDS 91_ RASAG 96_ SYISA 101_ LRVNK 106_ VIEIN 111_ PYLLG 116_ TMSGC 121_ AADCQ 126_ YWERL 131_ LAKEC 136_ RLYYL 141_ RNGER 146_ ISVSA 151_ ASKLL 156_ SNMMC 161_ QYRGM 166_ GLSMG 171_ SMICG 176_ WDKKG 181_ PGLYY 186_ VDEHG 191_ TRLSG 196_ NMFST 201_ GSGNT 206_ YAYGV 211_ MDSGY 216_ RPNLS 221_ PEEAY 226_ DLGRR 231_ AIAYA 236_ THRDS 241_ YSGGV 246_ VNMYH 251_ MKEDG 256_ WVKVE 261_ STDVS 266_ DLLHQ 271_YREAN
1: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes