Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein)
1_MLRAG 6_ APTGD 11_ LPRAG 16_ EVHTG 21_ TTIMA 26_ VEFDG 31_ GVVMG 36_ SDSRV 41_ SAGEA 46_ VVNRV 51_ FDKLS 56_ PLHER 61_ IYCAL 66_ SGSAA 71_ DAQAV 76_ ADMAA 81_ YQLEL 86_ HGIEL 91_ EEPPL 96_ VLAAA 101_ NVVRN 106_ ISYKY 111_ REDLS 116_ AHLMV 121_ AGWDQ 126_ REGGQ 131_ VYGTL 136_ GGMLT 141_ RQPFA 146_ IGGSG 151_ STFIY 156_ GYVDA 161_ AYKPG 166_ MSPEE 171_ CRRFT 176_ TDAIA 181_ LAMSR 186_ DGSSG 191_ GVIYL 196_ VTITA 201_ AGVDH 206_ RVILG 211_NELPK
1: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (PubMed:33727065, PubMed:34819510). The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues